作者：左霞，王晓慧，刘煜亮，陈虹

单位：

400042重庆市，重庆医科大学附属第一医院呼吸与危重症学科

Units：

Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

关键词：

脑出血；静脉血栓栓塞症；肝素；预防；综述

Keywords：

　Cerebral hemorrhage; Venous thromboembolism; Heparin; Prevention; Review

CLC：

R 743.34

DOI：

10.12114/j.issn.1008-5971.2024.00.115

Funds：

基金项目：重庆市卫生适宜技术推广项目（2022jstg005， ，2018jstg012，2017jstg31）

摘要：

静脉血栓栓塞症（VTE）包括深静脉血栓形成和肺血栓栓塞症，是脑出血常见且严重的并发症。目前 我国已启动VTE防治能力建设项目，主要防治措施包括机械预防和药物预防。近年来机械预防广泛使用，同时低分子 肝素、普通肝素等药物预防也逐渐应用于临床，但由于肝素可能增加脑出血患者血肿扩大或再出血风险，造成不良结 局，目前应用存在一定限制。本文介绍了肝素预防脑出血相关VTE的现状、有效性及安全性，为肝素在预防脑出血相 关VTE方面的应用提供了参考。

Abstract：

Venous thromboembolism (VTE) , including deep vein thrombosis and pulmonary thromboembolism, is a common and serious complication of cerebral hemorrhage. Nowadays, China has launched a VTE prevention and control capacity building project, and the main prevention includes mechanical prophylaxis and pharmacological prophylaxis. Mechanical prophylaxis has been widely used in recent years, while pharmacological prophylaxis such as low molecular weight heparin and unfractionated heparin has been gradually applied in the clinic, but the application of heparin is still insufficient since heparin may increase the risk of hematoma enlargement or rebleeding in cerebral hemorrhage patients, resulting in an adverse outcome. This article introduces the current status, effectiveness, and safety of heparin for the prevention of VTE related to cerebral hemorrhage, and provides a reference for the use of heparin in preventing VTE related to cerebral hemorrhage.

ReferenceList：