2024 年3 期 第32 卷
新进展![HTML下载 HTML下载](/Areas/201911120101/Content/img/icon_html.png)
![PDF下载 PDF下载](/Areas/201911120101/Content/img/icon_pdf.png)
高密度载脂蛋白在急性炎症反应中的作用
Role of High-Density Apolipoproteins in Acute Inflammatory Response
作者:王林霞1,2 ,李娜1,2 ,武冬民1,2 ,王耀勇1,2
- 单位:
- 1.032200山西省汾阳市,山西医科大学汾阳学院 2.032200山西省汾阳市,山西省 汾阳医院呼吸与危重症医学科
- Units:
- 1.Fenyang College of Shanxi Medical University, Fenyang 032200, China 2.Department of Respiratory and Critical Care Medicine, Fenyang Hospital of Shanxi Province, Fenyang 032200, China
- 关键词:
- 炎症;急性炎症反应;高密度载脂蛋白;综述
- Keywords:
- Inflammatory; Acute inflammatory response; High-density lipoprotein; Review
- CLC:
- R 364.5
- DOI:
- 10.12114/j.issn.1008-5971.2024.00.025
- Funds:
- 山西省卫健委医学重点科研攻关专项 (2020XM30);吕梁市引进高层次科技人才重点研发项目 (2021RC-2-31)
摘要:
高密度载脂蛋白是高密度脂蛋白中最重要的成分,其功能复杂且重要。研究表明,高密度载脂蛋白在 急性炎症反应中具有多重作用,其既可以发挥抗炎作用,也可以发挥促炎作用。本文通过检索、总结相关文献发现, 载脂蛋白(Apo)AⅠ、ApoAⅣ、ApoE、ApoM具有抗炎作用,ApoAⅡ、血清淀粉样蛋白A(SAA)具有促炎作用,而 ApoC、ApoD、ApoH、ApoJ、ApoL1、ApoF对急性炎症反应的作用不明确。
Abstract:
High-density lipoprotein is the most important component of high density lipoprotein, and its function is complex and important. Studies have shown that high-density apolipoproteins have multiple roles in acute inflammatory responses, including both anti-inflammatory and pro-inflammatory effects. In this paper, by searching and summarizing the relevant literature, it is found that apolipoprotein (Apo) AⅠ, ApoAⅣ, ApoE and ApoM have anti-inflammatory effects, ApoAⅡ and serum amyloid A (SAA) have pro-inflammatory effects, and ApoC, ApoD, ApoH, ApoJ, ApoL1 and ApoF have unclear effects on acute inflammatory response.
ReferenceList: