作者：曾守平1 ，林绍琼1 ，黄莺1 ，陈宜1 ，梁河1 ，赵强2

单位：

1.610500四川省成都市新都区中医医院儿科　2.400080重庆市九龙坡区中医院儿科

Units：

1.Department of Pediatrics, Xindu Hospital of Traditional Chinese Medicine, Chengdu 610500, China 2.Department of Pediatrics, Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing 400080, China

关键词：

咳嗽；儿童；数据挖掘；用药规律

Keywords：

Cough; Child; Data mining; Medication rules

CLC：

R 256.11

DOI：

10.12114/j.issn.1008-5971.2024.00.064

Funds：

四川省中医药管理局科学技术研究专项课题项目（2023MS043）；四川省名中医工作室建设项目〔川中医药办发 （2022）12号〕

摘要：

目的　基于数据挖掘分析林绍琼主任中医师治疗儿童慢性咳嗽的用药规律。方法　选取2021—2022年 在成都市新都区中医医院及重庆市九龙坡区中医院四川省名中医林绍琼工作室就诊的224例慢性咳嗽患儿。统计纳入 处方的中药，并建立数据库。应用中医传承辅助系统V2.5统计中药的四气、五味、归经分布及使用频次，并分析组方 规律、核心中药、新方组合。结果　共收录到386张处方，涉及105味中药，其总使用频次为6 367次。105味中药中， 四气为温、寒的中药使用频率较高，分别为44.12%、28.99%；五味为苦、辛的中药使用频率较高，分别为34.43%、 26.65%；归肺、胃、脾经中药的使用频率较高，分别为28.93%、17.65%、15.47%；使用频次≥190次的中药共4味，分 别为法半夏、紫菀、茯苓、陈皮；使用频次＞100次的中药组合共16组，获得11味核心中药，分别为法半夏、黄芩、 桔梗、陈皮、茯苓、苦杏仁、紫菀、浙贝母、款冬花、地龙、百部。通过无监督熵层次聚类算法共获得5组新方组 合。结论　林绍琼主任中医师从儿童慢性咳嗽病机出发，所选中药多性温寒、味辛苦，从肺、胃、脾经入手；共有11 味核心中药，分别为法半夏、黄芩、桔梗、陈皮、茯苓、苦杏仁、紫苑、浙贝母、款冬花、地龙、百部。

Abstract：

Objective To analyze the medication rules of chief physician Lin Shaoqiong in the treatment of chronic cough in children based on data mining. Methods From 2021 to 2022, 224 children with chronic cough in Sichuan Famous Traditional Chinese Medicine Lin Shaoqiong Studio of Xindu Hospital of Traditional Chinese Medicine and Jiulongpo District Hospital of Traditional Chinese Medicine were selected. The traditional Chinese medicine included in the prescription was counted and a database was established. The distribution of the four Qi, five flavors, channel tropism and frequency of use of traditional Chinese medicine, formula rules, core traditional Chinese medicine and new formula combinations were counted by the Traditional Chinese Medicine Inheritance Assistance System V2.5. Results A total of 386 prescriptions were included, involving 105 traditional Chinese medicines, with a total frequency of 6 367. Among the 105 traditional Chinese medicines, the frequency of use of warm and cold traditional Chinese medicines was higher, which was 44.12% and 28.99% respectively; the frequency of use of bitter and pungent traditional Chinese medicine was higher, which was 34.43% and 26.65% respectively; the use frequency of traditional Chinese medicine in lung, stomach and spleen meridians was higher, which was 28.93%, 17.65% and 15.47% respectively. There were 4 traditional Chinese medicines with the frequency of use ≥ 190 times, namely pinelliae rhizoma praeparatum, radix et rhizoma asteris, poria and citri reticulatae pericarpium; there were 16 groups of traditional Chinese medicine combinations with frequency of use > 100 times, and 11 core traditional Chinese medicines were obtained, which were pinelliae rhizoma praeparatum, scutellaria baicalensis, platycodonis radix, citri reticulatae pericarpium, poria, armeniacae semen amarum, radix et rhizoma asteris, fritillariae thunbergii bulbus, farfarae flos, pheretima and stemonae radix. A total of 5 groups of new prescriptions were obtained by unsupervised entropy hierarchical clustering algorithm. Conclusion The traditional Chinese medicine selected by chief physician Lin Shaoqiong from the pathogenesis of chronic cough in children is mostly warm and cold, with a hard taste, starting from the lung, stomach, and spleen meridians. There are 11 core traditional Chinese medicines, which are pinelliae rhizoma praeparatum, scutellaria baicalensis, platycodonis radix, citri reticulatae pericarpium, poria, armeniacae semen amarum, radix et rhizoma asteris, fritillariae thunbergii bulbus, farfarae flos, pheretima and stemonae radix.

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