作者：林平平1 ，梁健芬2 ，管颖芳1 ，王铭铭1 ，唐颖1 ，段雯雯1

单位：

1.530001广西壮族自治区南宁市，广西中医药大学　2.530023广西壮族自治区南宁市，广西中医药大学第 一附属医院老年病科、干部病区

Units：

1.Guangxi University of Traditional Medicine, Nanning 530001, China 2.Geriatrics and Cadre Ward, the First Affiliated Hospital of Guangxi University of Traditional Medicine, Nanning 530023, China

关键词：

再灌注损伤；脑缺血再灌注损伤；TLR4信号通路；中医药；综述

Keywords：

Reperfusion injury; Cerebral ischemia-reperfusion injury; TLR4 signaling pathway; Traditional Chinese medicine; Review

CLC：

R 619.9

DOI：

10.12114/j.issn.1008-5971.2024.00.037

Funds：

广西自然科学基金资助项目 （2018GXNSFAA138034）；广西中医药适宜技术开发与推广项目 （GZSY21-10）

摘要：

脑缺血再灌注损伤（CIRI）指通过血管再通手段恢复缺血脑组织血流供给后其功能未完全恢复，反而 引起脑功能障碍进一步加重的现象。Toll样受体4（TLR4）的主要作用是介导免疫应答和炎症反应，与CIRI的发生发展 密切相关。中医药治疗CIRI有独特优势，其可以通过多途径、多靶点调控TLR4相关信号通路、抑制脑组织炎症反应， 已逐渐成为治疗CIRI的研究热点。本文主要综述了TLR4相关信号通路在CIRI中的作用及中医药通过调控该信号通路治 疗CIRI的研究进展，以期为中医药防治CIRI提供客观依据。

Abstract：

Cerebral ischemia-reperfusion injury (CIRI) refers to the phenomenon that the function of ischemic brain tissue is not completely restored after the blood flow supply is restored by means of vascular recanalization, but the brain dysfunction is further aggravated. The main role of Toll-like receptor 4 (TLR4) is to mediate immune response and inflammatory response, which is closely related to the occurrence and development of CIRI. Traditional Chinese medicine has unique advantages in the treatment of CIRI, it can regulate TLR4 related signaling pathway and inhibit brain tissue inflammation through multiple pathways and multiple targets, and gradually becomes a research hotspot in the treatment of CIRI. This article reviews the role of TLR4 related signaling pathways in CIRI and the research progress of traditional Chinese medicine in the treatment of CIRI through regulating this signaling pathway, in order to provide an objective basis for the prevention and treatment of CIRI by traditional Chinese medicine.

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