作者：宁子艳1 ，梁正1 ，张慧敏1 ，靳宏光2 ，崔英子2

单位：

1.130117吉林省长春市，长春中医药大学　2.130021吉林省长春市，长春中医药大学附属医院心病中心

Units：

1.Changchun University of Chinese Medicine, Changchun 130117, China 2.Heart Disease Center, the Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China

关键词：

冠心病；经皮冠状动脉介入治疗；痰瘀互结证；中药；中医传承辅助平台；用药规律

Keywords：

Coronary disease; Percutaneous coronary intervention; Phlegm and blood stasis syndrome; Traditional Chinese medicine; Traditional Chinese medicine inheritance platform; Medication regularity

CLC：

R 541.4

DOI：

10.12114/j.issn.1008-5971.2024.00.047

Funds：

吉林省科技发展计划项目（20230203069SF）；新冠肺炎中医药应急科技项目（2022217）

摘要：

目的　基于中医传承辅助平台探讨中药治疗冠心病PCI后痰瘀互结证的用药规律。方法　计算机检 索中国知网、维普网、万方数据知识服务平台、中国生物医学文献数据库、PubMed、Cochrane Library中关于中药治 疗冠心病PCI后痰瘀互结证的随机对照试验，检索时限为建库至2023年9月。采用中医传承辅助平台（V2.5）统计药 物使用频次，中药的四气、五味、归经，并进行组方规律分析。结果　纳入63篇文献，共得到方剂63首，涉及中药 124味，总使用频次为652次，使用频次≥20次的中药有6味，依次为丹参、瓜蒌、半夏、茯苓、薤白、川芎。124味 中药中，四气为温、寒的中药使用频率较高，分别为45.40%、33.44%；五味为苦、甘、辛的中药使用频率较高，分 别为49.23%、43.87%、37.88%；归脾、心、肺、胃、肝经的中药使用频率较高，分别为43.10%、40.80%、39.72%、 38.50%、37.27%。设置支持度为19，置信度为0.70，共得到13组使用频次≥19次的中药组合，16条中药关联规则。结 论　治疗冠心病PCI后痰瘀互结证的中药主要包括丹参、瓜蒌、半夏、茯苓、薤白、川芎，其四气主要为温、寒，五 味主要为苦、甘、辛，主要归脾、心、肺、胃、肝经。

Abstract：

　Objective To investigate the medication regularity of traditional Chinese medicine in the treatment of phlegm and blood stasis syndrome after PCI in coronary heart disease based on the traditional Chinese medicine inheritance platform. Methods The database of CNKI, VIP, Wanfang Data, Chinese Biomedical Database, PubMed and Cochrane Library were retrieved to search for randomized controlled trial on the traditional Chinese medicine in the treatment of phlegm and blood stasis syndrome after PCI in coronary heart disease. The search time was from the establishment of the database to September The traditional Chinese medicine inheritance platform (V2.5) was used to count the the frequency of drug use, the four Qi, five flavors, and channel tropism of traditional Chinese medicine, and analyse the formation rules. Results A total of 63 articles were included, and a total of 63 prescriptions were obtained, involving 124 flavors of traditional Chinese medicine, and the total frequency of use was 652 times. Six flavors of traditional Chinese medicine were used ≥ 20 times, which were Danshen, fructus trichosanthis, pinellia ternata, poria cocos, allium macrostemon and ligusticum wallichii. Among the 124 flavors of traditional Chinese medicine, the frequency of use of traditional Chinese medicine with warmth and coldness in the four Qi was relatively high, at 45.40% and 33.44%, respectively; the frequency of use of traditional Chinese medicine with mainly bitter, sweet and pungent in the five flavors was relatively high, at 49.23%, 43.87%, and 37.88%, respectively; the frequency of use of traditional Chinese medicine with spleen meridian, heart meridian, lungs meridian, stomach meridian and liver meridian was relatively high, at 43.10%, 40.80%, 39.72%, 38.50%, and 37.27%, respectively. Set the support level to 19, and the confidence level to 0.70, and 13 traditional Chinese drugs combinations with using frequency of ≥ 19 times and 16 association rules of traditional Chinese drugs were obtained. Conclusion The traditional Chinese medicine in the treatment of phlegm and blood stasis syndrome after PCI in coronary heart disease are Danshen, fructus trichosanthis, pinellia ternata, poria cocos, allium macrostemon and ligusticum wallichii. The four Qi of them are mainly warmth and coldness, the five flavors of them are mainly bitter, sweet and pungent, and they are mainly attributed to the spleen meridian, heart meridian, lungs meridian, stomach meridian and liver meridian.

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