作者：王晓霞1 ，曹学华2 ，熊浪宇1 ，孙妍3 ，胡婉琴1 ，向凤1 ，贾钰1

单位：

1.610075四川省成都市，成都中医药大学护理学院　2.610072四川省成都市，四川省人民医院妇科　 3.610072四川省成都市，四川省人民医院急诊外科

Units：

1.School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China 2.Gynecology Department, Sichuan Provincial People's Hospital, Chengdu 610072, China 3.Department of Emergency Surgery, Sichuan Provincial People's Hospital, Chengdu 610072, China

关键词：

冠心病；衰弱；老年人；患病率；影响因素；Meta分析

Keywords：

Coronary disease; Frailty; Aged; Prevalence; Influencing factors; Meta-analysis

CLC：

R 541.4

DOI：

10.12114/j.issn.1008-5971.2023.00.329

Funds：

四川省科技重点研发项目（2023YFS0068）

摘要：

目的　采用Meta分析方法探讨中国老年冠心病患者衰弱患病率及影响因素。方法　计算机检索中国知 网、维普网、中国生物医学文献数据库、万方数据知识服务平台、Web of Science、PubMed、Cochrane Library、Embase 数据库公开发表的中国老年冠心病患者衰弱患病率及影响因素的横断面研究、队列研究及病例对照研究。检索时限 为建库至2023年5月。由两名研究者独立进行文献筛选、资料提取及质量评价，使用Stata 15.0软件进行Meta分析。结 果　本研究纳入29篇文献，包括8 022例老年冠心病患者，其中发生衰弱2 651例。Meta分析结果显示，中国老年冠心 病患者衰弱患病率为32.7%〔95%CI（27.4%～38.0%）〕。亚组分析结果显示，不同发表年份、研究地区、衰弱评估 工具文献的中国老年冠心病患者衰弱患病率比较，差异有统计学意义（P＜0.05）。Meta分析结果显示，年龄、婚姻 状况、独居、近1年跌倒史、文化水平、睡眠状况、步速、营养状况、Barthel指数、NYHA分级、查尔森合并症指数 （CCI）、冠心病特异性指数、脑钠肽、25-羟维生素D3〔25（OH）D3〕、清蛋白、焦虑、抑郁状况是中国老年冠心 病患者发生衰弱的影响因素（P＜0.05）。结论　现有证据显示，中国老年冠心病患者衰弱患病率为32.7%，患病率 较高；年龄、婚姻状况、独居、近1年跌倒史、文化水平、睡眠状况、步速、营养状况、Barthel指数、NYHA分级、 CCI、冠心病特异性指数、脑钠肽、25（OH）D3、清蛋白、焦虑、抑郁状况是中国老年冠心病患者发生衰弱的影响 因素。

Abstract：

Objective To explore the incidence and influencing factors of frailty in elderly patients with coronary heart disease in China through meta-analysis. Methods Databases including the CNKI, VIP, CBM, Wanfang Data, Web of Science, PubMed, Cochrane Library, Embase, were retrieved to search for cross-sectional studies, cohort studies and case control studies on the incidence and influencing factors of frailty in elderly patients with coronary heart disease in China. The search deadline was from the respective databases to May 2023. Literature screening, data extraction and quality assessment were performed independently by two researchers. Stata 15.0 was used for meta-analysis. Results A total of 29 articles were included, and involving 8 022 elderly patients with coronary heart disease, among which 2 651 experienced frailty. The meta-analysis results showed that the incidence of frailty in elderly patients with coronary heart disease in China was 32.7% [95%CI (27.4%- 38.0%) ] . The results of subgroup analysis showed that there was statistically significant difference in the incidence of frailty in elderly patients with coronary heart disease in China in literature with different study year, study area and frailty assessment tools (P < 0.05) . Meta-analysis results showed that age, marital status, living alone, history of falls in the past one year, education level, sleep status, gait speed, nutritional status, Barthel's index, NYHA grading, Chalson's Comorbidities Index (CCI) , coronary heart disease specificity index, brain natriuretic peptide, 25-hydroxyvitamin D3 [25 (OH) D3] , albumin, anxiety, and depression status were influencing factors of frailty in elderly patients with coronary heart disease in China (P < 0.05) . Conclusion The available evidence shows that the incidence of frailty in elderly patients with coronary heart disease in China is 32.7%, the prevalence rate is high. Age, marital status, living alone, history of falls in the past one year, education level, sleep status, gait speed, nutritional status, Barthel's index, NYHA grading, CCI, coronary heart disease specificity index, brain natriuretic peptide, 25 (OH) D3, albumin, anxiety, and depression status are influencing factors of frailty in elderly patients with coronary heart disease in China.

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