作者：陈平 1 ，吴文兵2 ，任思冲3 ，米佳丽1

单位：

1.629000四川省遂宁市中心医院药学部　2.646000四川省泸州市，西南医科大学基础医学院生物化学与分 子生物学教研室　3.610500四川省成都市，成都医学院第一附属医院肾内科

Units：

1.Department of Pharmacy, Suining Central Hospital, Suining 629000, China 2.Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences of Southwest Medical University, Luzhou 646000, China 3.Department of Nephrology, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China

关键词：

肺炎；惠普尔养障体；宏基因组二代测序；病例报告

Keywords：

Pneumonia; Tropheryma whipplei; Metagenomic next generation sequencing; Case reports

CLC：

　R 563.1

DOI：

10.12114/j.issn.1008-5971.2023.00.243

Funds：

国家自然科学基金资助项目（81803967）；四川省医 院协会2022年度青年药师科研专项资金项目（22018）

摘要：

惠普尔养障体（TW）重症肺炎是由TW感染引起的罕见病，传统检测方法不易获得其病原学证据，误 诊率极高，故其早期诊断与治疗仍面临巨大挑战。宏基因二代测序（mNGS）可检测到传统检测手段无法检测到的罕 见病原体，使得TW检出率不断提高。本文报道1例支气管肺泡灌洗液mNGS诊断为TW感染的重症肺炎患者，给予头孢 曲松联合复方磺胺甲噁唑治疗，患者病情好转。

Abstract：

Tropheryma whipplei (TW) severe pneumonia caused by TW is a rare disease. Traditional detection methods are difficult to obtain its etiological evidence, resulting in the misdiagnosis rate is extremely high. Early diagnosis and treatment are still huge clinical challenges. Metagenomic next-generation sequencing (mNGS) can detect rare pathogens that cannot be detected by conventional detection methods, leading to an increasing detection rate of TW. This article reports one case of TW severe pneumonia diagnosed by mNGS, ceftriaxone combined with compound sulfamethoxazole was administered, and the patient had good prognosis.

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