作者：郭爽1 ，李树仁2 ，郝潇2 ，赵文静1 ，李健超3

单位：

1.050011河北省石家庄市，河北医科大学研究生学院　2.050057河北省石家庄市，河北省 人民医院心内一科　3.075000河北省张家口市，河北北方学院研究生学院

Units：

1.Graduate School of Hebei Medical University, Shijiazhuang 050011, China 2.Department of Cardiology, Hebei General Hospital, Shijiazhuang 050057, China 3.Graduate School of Hebei North University, Zhangjiakou 075000, China

关键词：

　心房颤动；心力衰竭；心房颤动介导的心肌病；钙稳态失衡；综述

Keywords：

　Atrial fibrillation; Heart failure; Atrial fibrillation mediated cardiomyopathy; Calcium homeostasis imbalance; Review

CLC：

R 541.75 R 541.62

DOI：

10.12114/j.issn.1008-5971.2023.00.287

Funds：

摘要：

心房颤动介导的心肌病（AMC）指阵发性或持续性心房颤动（AF）引起心脏扩大，导致心室收缩与舒张 功能受损、左心室射血分数下降，最终引发心力衰竭（HF），患者恢复窦性心律或心室率得到严格控制后，心脏扩大与 HF症状能够得到完全性或几乎完全性逆转。临床中AMC的发病率并不低，早期诊断、干预可以明显改善患者预后，但目 前临床在排除其他病因后才能诊断AMC，缺乏特异性诊断指标，且对于AMC的病理过程尚不清楚。本文从钙稳态失衡入 手，分别介绍了其在AF和HF中的作用，进而分析其与AMC的关系，以期为AMC的临床诊断和治疗提供方向。

Abstract：

Atrial fibrillation mediated cardiomyopathy (AMC) refers to paroxysmal or persistent atrial fibrillation (AF) causing heart enlargement, resulting in impaired ventricular systolic and diastolic function, decreased left ventricular ejection fraction, and ultimately heart failure (HF) . The symptoms of heart enlargement and HF can be completely or almost completely reversed after the patient returns to sinus rhythm or ventricular rate is strictly controlled. The clinical incidence of AMC is not low, and early diagnosis and intervention can significantly improve the prognosis of patients. However, at present, the diagnosis of AMC can only be made after excluding other causes, which lacks specific diagnostic indicators, and the pathological process of AMC is still unclear. This article starts with calcium homeostasis imbalance, introduces its role in AF and HF, and analyzes its relationship with AMC, in order to provide direction for the clinical diagnosis and treatment of AMC.

ReferenceList：