作者：张慧敏1 ，梁正1 ，宁子艳1 ，靳宏光2 ，崔英子2

单位：

1.130117吉林省长春市，长春中医药大学　2.130021吉林省长春市，长春中医药大学附属医院心病中心 通信作者：靳宏光，E-mail：7420465@qq.com

Units：

1.Changchun University of Chinese Medicine, Changchun 130117, China 2.Heart Disease Center, the Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China

关键词：

颈动脉疾病；动脉粥样硬化；痰瘀；中药；中医传承辅助平台；用药规律

Keywords：

Carotid artery diseases; Atherosclerosis; Phlegm and blood stasis; Traditional Chinese medicine; Assistant platform of traditional Chinese medicine inheritance; Medication regularity

CLC：

R 543.4

DOI：

10.12114/j.issn.1008-5971.2023.00.248

Funds：

吉林省科技发展计划项目（20230203069SF，020100502）

摘要：

目的　基于中医传承辅助平台探讨痰瘀论治颈动脉粥样硬化（CAS）的用药规律。方法　计算机检索 中国知网、维普网、万方数据知识服务平台、中国生物医学文献数据库、PubMed、Cochrane Library中关于痰瘀论治 CAS的随机对照试验，检索时限为建库至2023年7月。应用中医传承辅助平台（V2.5）进行描述性统计、关联规则分 析，并对核心中药进行网络可视化。结果　最终纳入文献62篇，共得到62首中药处方，涉及中药137味，总使用频次 646次，其中使用频次≥20次的中药7味，依次为丹参、川芎、黄芪、水蛭、茯苓、山楂、泽泻。137味中药的四气以 温、寒为主；五味以苦、甘为主；主要归肝、脾经。设置支持度为12，置信度为0.600，以中药组合使用频次进行降序 排列，共得到19个使用频次≥10次的中药组合，12条中药关联规则。核心中药网络可视化图分析结果显示，共12味核 心中药。结论　痰瘀论治CAS中药主要包括丹参、川芎、黄芪、水蛭、茯苓、山楂、泽泻，其四气以温、寒为主，五 味以苦、甘为主，主要归肝、脾经。

Abstract：

Objective To investigate the medication regularity of phlegm and blood atasis in the treatment of carotid atherosclerotic (CAS) based on the platform of traditional Chinese medicine inheritance. Methods The database of CNKI, VIP, Wanfang Data, Chinese Biomedical Database, PubMed and Cochrane library were retrieved to search for randomized controlled trial on the phlegm and blood atasis in the treatment of CAS. The search time was from the establishment of the database to July The traditional Chinese medicine inheritance platform (V2.5) was used for descriptive statistics and association rules analysis, and network visualization of core traditional Chinese medicine. Results A total of 62 articles were included, and a total of 62 prescriptions were obtained. There were 137 flavors of traditional Chinese medicine involved, and the total frequency of use was 662 times, of which 7 flavors of traditional Chinese medicine with frequency of ≥ 20 times were followed by salvia miltiorrhiza, rhizome of Chuanxiong, astragalus membranaceus, leech, Poria cocos, hawthorn and rhizoma alismatis. The four Qi of 137 flavors of traditional Chinese medicine was mainly warm and cold, and the five flavors of them were mainly bitter and sweet; and they were mainly attributed to the liver meridian and spleen meridian. Set the support level to 12, the confidence level to 0.600, and the Chinese medicine combination frequency was sorted according to the frequency of use, and 19 traditional Chinese drugs combinations with using frequency of ≥10 times and 12 association rules of traditional Chinese drugs were obtained. The results of network visualization of core traditional Chinese medicine analysis showed that there were 12 core traditional Chinese drugs. Conclusion The traditional Chinese medicine of phlegm and blood atasis in the treatment of CAS mainly includes salvia miltiorrhiza, rhizome of Chuanxiong, astragalus membranaceus, leech, Poria cocos, hawthorn and rhizoma alismatis. The four Qi of them are mainly warm and cold, the five flavors of them are mainly bitter and sweet, and they are mainly attributed to the liver meridian and spleen meridian.

ReferenceList：