作者：王晓，刘琳娜，尚莉丽

单位：

233600安徽省亳州市涡阳县，安徽中医药大学第一附属医院涡阳分院儿科

Units：

Department of Pediatrics, Guoyang Branch, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Guoyang 233600, China

关键词：

肺炎；小儿肺咳颗粒；沙丁胺醇；炎症反应；血清淀粉样蛋白A；可溶性白介素2受体

Keywords：

Pneumonia; Xiao'er Feike granules; Albuterol; Inflammatory reaction; Serum amyloid A protein; Soluble interleukin-2 receptor

CLC：

R 563.1

DOI：

10.12114/j.issn.1008-5971.2023.00.324

Funds：

摘要：

目的　分析小儿肺咳颗粒联合沙丁胺醇对小儿肺炎患儿炎症反应及血清淀粉样蛋白A（SAA）、可溶 性白介素2受体（sIL-2R）水平的影响。方法　选取2019年3月至2022年3月安徽中医药大学第一附属医院涡阳分院收 治的小儿肺炎患儿170例为研究对象。按照随机数字表法将患儿分为A组与B组，每组85例。A组患儿采用沙丁胺醇治 疗，B组患儿在A组的基础上采用小儿肺咳颗粒治疗，两组均治疗2周。比较两组临床疗效、症状（包括咳嗽、气喘、 发热、肺啰音）消失时间、住院时间和治疗前后肺功能指标〔用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、 呼气峰流量（PEF）〕、炎症反应指标〔超敏C反应蛋白（hs-CRP）、降钙素原（PCT）〕、SAA水平、sIL-2R水平 及治疗期间不良反应发生率。结果　B组治疗总有效率高于A组（P＜0.05）。B组咳嗽、气喘、发热、肺啰音消失 时间及住院时间短于A组（P＜0.05）。治疗后，B组FVC、FEV1大于A组，PEF快于A组（P＜0.05）；A组、B组治 疗后FVC、FEV1分别大于本组治疗前，PEF分别快于本组治疗前（P＜0.05）。治疗后，B组hs-CRP、PCT低于A组 （P＜0.05）；A组、B组治疗后hs-CRP、PCT分别低于本组治疗前（P＜0.05）。治疗后，B组SAA、sIL-2R水平低于A 组（P＜0.05）；A组、B组治疗后SAA、sIL-2R水平分别低于本组治疗前（P＜0.05）。两组治疗期间不良反应发生率 比较，差异无统计学意义（P＞0.05）。结论　小儿肺咳颗粒联合沙丁胺醇可有效提高小儿肺炎患儿的临床疗效，缩短 患儿症状消失时间及住院时间，提高肺功能，减轻炎症反应，降低SAA、sIL-2R水平，且安全性较好。

Abstract：

Objective To analyze the effect of Xiao'er Feike granule combined with salbutamol on inflammatory response and serum amyloid A protein (SAA) and soluble interleukin-2 receptor (sIL-2R) levels in children with infantile pneumonia. Methods From March 2019 to March 2022, 170 children with infantile pneumonia who were admitted to Guoyang Branch, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected as the study subjects. According to the random number table method, the children were divided into group A and group B, with 85 cases in each group. Children in group A were treated with salbutamol, while children in group B were treated with Xiao'er Feike granules on the basis of group A. Both groups were treated for 2 weeks. The clinical efficacy, disappearance time of symptoms (including cough, asthma, fever, lung rale) , hospitalization time, lung function indicators [forced vital capacity (FVC) , forced expiratory volume in one second (FEV1) , peak expiratory flow (PEF) ] , inflammatory response indicators [hypersensitive C-reactive protein (hs-CRP) , procalcitonin (PCT) ] , SAA level and sIL-2R level before and after treatment, and incidence of adverse reactions during treatment were compared between the two groups. Results The total effective rate of treatment in group B was higher than that in group A (P < 0.05) . The disappearance time of cough, asthma, fever and lung rale and hospitalization time in group B were shorter than those in group A (P < 0.05) . After treatment, FVC and FEV1 in group B were higher than those in group A, and PEF was faster than that in group A (P < 0.05) . After treatment, FVC and FEV1 in group A and group B were higher than those before treatment, while PEF was faster than that before treatment, respectively (P < 0.05) . After treatment, hs-CRP and PCT in group B were lower than those in group A (P < 0.05) . After treatment, hs-CRP and PCT in group A and group B were lower than those before treatment respectively (P < 0.05) . After treatment, the levels of SAA and sIL-2R in group B were lower than those in group A (P < 0.05) . After treatment, the levels of SAA and sIL-2R in group A and group B were lower than those before treatment respectively (P < 0.05) . There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups (P > 0.05) . Conclusion Xiao'er Feike granule combined with salbutamol can effectively improve the clinical efficacy of children with infantile pneumonia, shorten the time for symptom disappearance and hospitalization, improve lung function, reduce inflammatory reactions and levels of SAA and sIL-2R, and has good safety.

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