作者：淡一航 ，杨岭 ，张宇 ，符珍珍 ，彭瑜 ，张钲

单位：

1.730000甘肃省兰州市，兰州大学第一临床医学院 2.730000甘肃省兰州市，兰州大学第一医院心脏中心 甘肃省心血 管疾病重点实验室

Units：

1.The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China 2.Heart Center, the First Hospital of Lanzhou University/Key Laboratory of Cardiovascular Diseases of Gansu Province, Lanzhou 730000, China

关键词：

心肌再灌注损伤；双特异性磷酸酶1；综述

Keywords：

Myocardial ischemia-reperfusion injury; Dual specificity phosphatase 1; Review

CLC：

R 542.2

DOI：

10.12114/j.issn.1008-5971.2023.00.320

Funds：

甘肃省科技计划项目（18JR2FA005）

摘要：

双特异性磷酸酶（DUSP）1是DUSP蛋白家族的重要成员，具有使酪氨酸以及丝/苏氨酸残基去磷酸化 的双重作用，其还在细胞生长周期的调控、氧化应激以及炎症等多种病理生理过程中发挥重要作用。近年来多项研究 指出，DUSP1参与心肌梗死、心力衰竭、心室重构和心肌纤维化等多种心血管疾病的发生发展，并可通过介导信号转 导通路、逆转细胞凋亡、抑制炎症反应等方式减轻心肌缺血再灌注损伤（MIRI），从而改善患者心功能。本文首先分 析了MIRI的病理生理机制，然后综述了DUSP1的结构、生物学功能及其在MIRI中的作用机制，以期为DUSP1作为MIRI 的治疗靶点提供理论依据。

Abstract：

Dual specificity phosphatase (DUSP) 1 is an important member of the DUSP protein family, which can dephosphorylate tyrosine and serine/threonine residues. It also plays an important role in various pathophysiological processes such as cell growth cycle regulation, oxidative stress and inflammation. In recent years, a number of studies have pointed out that DUSP1 is involved in the occurrence and development of a variety of cardiovascular diseases such as myocardial infarction, heart failure, ventricular remodeling and myocardial fibrosis, and can alleviate myocardial ischemia-reperfusion injury (MIRI) by mediating signal transduction pathways, reversing apoptosis and inhibiting inflammatory response, thereby improving cardiac function of patients. In this paper, we first analyzed the pathophysiological mechanism of MIRI, and then reviewed the structure, biological function and action mechanism of DUSP1 in MIRI, in order to provide theoretical basis for DUSP1 as a therapeutic target of MIRI.

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