作者：杨燕，蔡静，吴远华，曹丽平

单位：

1.550002贵州省贵阳市，贵州中医药大学　2.550001贵州省贵阳市，贵州中医药大学第一附属医院神经内科

Units：

1.Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China2.Department of Neurology, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang550001, China

关键词：

髓鞘少突胶质细胞糖蛋白；髓鞘少突胶质细胞糖蛋白抗体相关疾病；化痰熄风法；病例报告

Keywords：

Myelin-oligodendrocyte glycoprotein; Myelin-oligodendrocyte glycoprotein antibody disease; Formula forclearing phlegm and calming endogenous wind; Case reports

CLC：

R 341.32

DOI：

10.12114/j.issn.1008-5971.2023.00.248

Funds：

贵州省优秀科技教育人才省长专项资金项目（2010144）；贵州中医药大学科研项目（3040-040210134）；博士启动基金〔GYZYYFY-BS-2018（07）〕

摘要：

髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）是神经科罕见病，以癫痫发作为主要表现者更为罕见。目前尚无关于MOGAD治疗的统一指南，其治疗方案主要依据个案报道的经验，且患者后期易复发，复发越频繁，患者越容易遗留神经功能障碍。本文报道1例以癫痫发作为主要表现的MOGAD患者，在常规免疫抑制剂、抗癫痫治疗、抗病毒治疗基础上，予以化痰熄风法，方选半夏白术天麻汤加减，治疗后其症状明显好转，血清、脑脊液髓鞘少突胶质细胞糖蛋白（MOG）抗体转阴，且未复发。本文为临床上诊断及治疗MOGAD提供了一定经验。

Abstract：

Myelin-oligodendrocyte glycoprotein antibody disease (MOGAD) is a rare neurological disease, andepilepsy as the main manifestation is even rarer. At present, there is no unified guideline for the treatment of MOGAD, whichis mainly based on the experience of case reports. In addition, patients are prone to recurrence in the later stage, and the morefrequent the recurrence, the more likely the patient is to leave behind neurological dysfunction. This article reports a case ofMOGAD patient with epilepsy as the main manifestation. On the basis of conventional immunosuppressive agents, anti epilepsy,and antiviral therapy, the patient was treated with formula for clearing phlegm and calming endogenous wind, and the prescriptionof Banxia Baizhu Tianma decoction was modified. After treatment, the symptoms of the patient improved significantly, the serumand cerebrospinal fluid myelin-oligodendrocyte glycoprotein (MOG) antibodies turned negative, and the patient didn't recur. Thispaper provides certain experience for the clinical diagnosis and treatment of MOGAD.

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