作者：陈保江，胡存静，栾仲秋

单位：

1.150040黑龙江省哈尔滨市，黑龙江中医药大学研究 生院 2.150040黑龙江省哈尔滨市，黑龙江中医药大学第一附属医院肝 脾胃科 3.150040黑龙江省哈尔滨市，黑龙江中医药大学第一附属医院肾 病科

Units：

1.Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China 2.Department of Liver, Spleen and Stomach, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China 3.Department of Nephrology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China

关键词：

糖尿病肾病；线粒体功能障碍；信号通路；综述

Keywords：

Diabetic nephropathies; Mitochondrial dysfunction; Signal pathway; Review

CLC：

R 587.24

DOI：

10.12114/j.issn.1008-5971.2023.00.262

Funds：

黑龙江省自然科学基金资助项目（LH2022H073）； 黑龙江省中医药管理局项目（ZHY18-001）；黑龙江中医药大学医 院管理研究项目（YG18005）；黑龙江中医药大学教育教学研究项目 （XJJY2018007）

摘要：

糖尿病肾病（DKD）是糖尿病患者死亡的主要原因，也是终末期肾脏病的主要原因，其发病机制复 杂，是国内外的研究热点。线粒体作为供能的主要场所，对DKD的发生发展具有至关重要的作用。本文通过检索、 分析相关文献，综述了线粒体功能障碍与DKD相关信号通路〔NOX信号通路、BNIP3/NIX信号通路、转化生长因子 （TGF）-β1/Smads信号通路、过氧化物酶体增殖物激活受体γ辅激活子1α（PGC-1α）信号通路、Notch信号通 路〕的关系，以期为防治DKD、延缓其进入终末期肾脏病提供新的治疗靶点及策略。

Abstract：

Diabetic kidney disease (DKD) is the main cause of death in diabetic patients and the main cause of end stage renal disease. Its pathogenesis is complex and is a research hotspot at home and abroad. Mitochondria, as the main site of energy supply, plays a vital role in the occurrence and development of DKD. This article reviews the relationship between mitochondrial dysfunction and DKD-related signaling pathways [NOX signaling pathway, BNIP3/NIX signaling pathway, transforming growth factor (TGF)-β1/Smads signaling pathway, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) signaling pathway, Notch signaling pathway] through searching and analyzing the relevant literature, in order to provide new therapeutic targets and strategies for the prevention and treatment of DKD and delaying its progression to end stage renal disease.

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