作者：张曾宇，陈嘉敏，卢圣花，胡雅琪，刘建和

单位：

1.410208湖南省长沙市，湖南中医药大学中医学院　2.410208湖南省长沙市，湖南中医药大学中西医结合学院　3.410208湖南省长沙市，湖南中医药大学研究生院　4.410021湖南省长沙市，湖南中医药大学第一附属医院，国家中医心血管病临床医学研究中心分中心

Units：

1.School of Traditional Medicine, Hunan University of Chinese Medicine, Changsha 410208, China2.College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208,China3.Graduate School of Hunan University of Traditional Chinese Medicine, Changsha 410208, China4.The First Affiliated Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center forChinese Medicine Cardiology, Changsha 410021, China

关键词：

　心肌再灌注损伤；中药；苷类；信号通路；综述

Keywords：

Myocardial reperfusion injury; Traditional Chinese drugs; Glycosides; Signaling pathway; Review

CLC：

R 542.2

DOI：

10.12114/j.issn.1008-5971.2023.00.202

Funds：

湖南省中医药管理局科研计划重点项目（2021011）；国家级大学生创新创业训练计划项目（S202110541045）

摘要：

急性心肌梗死（AMI）是冠状动脉急性、持续缺血缺氧导致的心肌细胞坏死，是最严重的冠心病类型。目前，再灌注治疗是AMI的主要治疗方案，但缺血心肌恢复血流灌注可能引起心肌缺血再灌注损伤（MIRI），进而影响患者的预后。因此，如何预防MIRI已成为AMI患者再灌注治疗过程中亟须解决的问题。中医药因多靶点、多通路、不良反应少、性价比高等优势而获得国内外学者的关注。研究表明，中医药中的苷类有效成分可通过调控多条信号通路而发挥抗心肌细胞凋亡、抗炎、抗氧化应激等作用，进而保护心肌细胞，减轻MIRI。基于此，本文从信号通路角度探讨了苷类中药单体减轻MIRI的机制，旨在为临床上采用苷类中药单体治疗MIRI提供理论支持。

Abstract：

Acute myocardial infarction (AMI) is myocardial cell necrosis caused by acute and continuous ischemiaand hypoxia of coronary artery, which is the most serious type of coronary heart disease. At present, reperfusion therapy is themain treatment for AMI, but the recovery of blood perfusion in ischemic myocardium may cause myocardial ischemia-reperfusioninjury (MIRI) , which in turn affects the prognosis of patients. Therefore, how to prevent MIRI has become an urgent problem to besolved in the process of reperfusion therapy for AMI patients. Traditional Chinese medicine has attracted the attention of scholarsat home and abroad with the advantages of multi-target, multi-channel, less adverse reactions and high cost performance. Studieshave shown that the effective components of glycosides in traditional Chinese medicine can exert anti-myocardial cell apoptosis,anti-inflammatory, anti-oxidative stress and other effects by regulating multiple signaling pathways, thereby protecting myocardialcells and reducing MIRI. Based on this, this paper discusses the mechanism of glycosides Chinese medicine monomer for reducingMIRI from the perspective of signaling pathway, aiming to provide theoretical support for the clinical use of glycosides Chinesemedicine monomer in the treatment of MIRI.

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