作者：徐圣洁，席加秋，吴涛，王中琳

单位：

1.250014山东省济南市，山东中医药大学第一临床医学院2.250014山东省济南市，山东中医药大学3.250014山东省济南市，山东中医药大学中医学院4.250014山东省济南市，山东中医药大学附属医院神经内一科

Units：

1.Shandong University of Traditional Chinese Medicine First Clinical Medical College, Jinan 250014, China2.Shandong University of Traditional Chinese Medicine, Jinan 250014, China3.Shandong University of Traditional Chinese Medicine College of Traditional Chinese Medicine, Jinan 250014, China4.Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China

关键词：

肥胖症；肠-脑轴；棕色脂肪组织；综

Keywords：

Obesity; Brain-gut axis; Brown adipose tissue; Review

CLC：

R 589.25

DOI：

10.12114/j.issn.1008-5971.2023.00.212

Funds：

齐鲁内科血浊学术流派传承工作室项目（鲁卫函［2021］45号）；山东省中医药科技项目（2020M004）；山东省中医药科技发展计划项目（2019-0108）

摘要：

肠-脑轴是由肠道菌群、短链脂肪酸、肠道内分泌细胞及肠道激素、神经系统〔中枢神经系统（CNS）、肠神经系统（ENS）、自主神经系统（ANS）及其相关分支〕、神经内分泌信号、免疫系统组成的一条双向调节通路。随着肥胖在全世界范围内大流行，人们逐渐认识到棕色脂肪组织（BAT）在脂肪代谢中具有重要作用。本文主要综述了肠-脑轴组成及其影响BAT产热的机制，以期从肠-脑轴与BAT的角度为防治肥胖提供潜在方案。

Abstract：

The gut-brain axis is a bidirectional regulatory pathway composed of intestinal flora, short-chain fatty acids,intestinal endocrine cells and intestinal hormones, nervous system [central nervous system (CNS) , enteric nervous system (ENS) ,autonomic nervous system (ANS) and their related branches] , neuroendocrine signals, and immune system. With the prevalenceof obesity worldwide, people gradually realize that brown adipose tissue (BAT) plays an important role in fat metabolism. Thisarticle mainly reviews the composition of gut-brain axis and the mechanism of it affecting BAT thermogenesis, in order to providea potential solution for the prevention and treatment of obesity from the perspective of gut-brain axis and BAT.

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