作者：关静，黄凡克，周伊璐，李冰清，陈余文，王悦，孙培媛，吕建峰

单位：

1.443000湖北省宜昌市，三峡大学心脑血管疾病研究所2.443000湖北省宜昌市，三峡大学附属仁和医院心血管内科

Units：

1.Institute of Cardiovascular and Cerebrovascular Diseases, China Three Gorges University, Yichang 443000, China2.Internal Medicine-Cardiovascular Department, Affiliated Renhe Hospital of China Three Gorges University, Yichang443000, China

关键词：

心力衰竭；缺血缺氧性心肌损伤；黄芪甲苷；综述

Keywords：

Heart failure; Ischemic hypoxia myocardial injury; Astragaloside Ⅳ; Review

CLC：

R 541.62

DOI：

10.12114/j.issn.1008-5971.2023.00.180

Funds：

湖北省卫生健康委员会科研项目（WJ2021F061）

摘要：

黄芪甲苷（AS-Ⅳ）是中药黄芪的主要有效成分，在心血管疾病中具有突出作用，其可保护心肌细胞免受缺血缺氧性损伤，且具有抗炎、增强心肌收缩力、改善心肌舒张功能、减轻血管内皮功能障碍、促进血管新生等保护心脏结构及增强心脏功能的作用。心力衰竭患者心肌处于缺血缺氧状态，而AS-Ⅳ能减轻缺血缺氧并发挥心脏保护作用。本文通过分析相关文献发现，心力衰竭患者发生缺血缺氧性心肌损伤的机制包括离子失衡、氧化应激、线粒体能量代谢异常及血管生成障碍，而AS-Ⅳ可能通过调节离子平衡、减轻氧化应激、改善线粒体功能、促进血管生成来保护心力衰竭患者心肌细胞免受缺血缺氧性损伤。

Abstract：

Astragaloside Ⅳ (AS-Ⅳ) is the main effective component of astragalus membranaceus, which playsa prominent role in cardiovascular diseases. It can protect myocardial cells from ischemia and hypoxia injury, and has antiinflammatory, enhancing myocardial contractility, improving myocardial diastolic function, reducing vascular endothelialdysfunction, promoting angiogenesis and other functions to protect the heart structure and enhance the heart function. In patientswith heart failure, the myocardium is in a state of ischemia and hypoxia, while AS-Ⅳ can alleviate ischemia and hypoxia andplay a cardiac protective role. Based on the analysis of relevant literature, it is found that the mechanisms of ischemic and anoxicmyocardial injury in patients with heart failure include ion imbalance, oxidative stress, abnormal mitochondrial energy metabolismand angiogenesis disorders, while AS-Ⅳ may protect myocardial cells from ischemic and anoxic injury in patients with heartfailure by regulating ion balance, reducing oxidative stress, improving mitochondrial function and promoting angiogenesis.

ReferenceList：