作者：李思平，刘丽平，周荣

单位：

1.兰州大学第一临床医学院2.兰州大学第一医院急诊科

Units：

1.The 1st School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China 2.Department of Emergency, the First Hospital of Lanzhou University, Lanzhou 730000, China

关键词：

动脉瘤,夹层; 主动脉夹层; 长链非编码RNA; 生物标志物; 发病机制;

Keywords：

Aneurysm, dissecting; Aortic dissection; Long non-coding RNA; Biomarker; Mechanism of pathogenesis

CLC：

DOI：

10.12114/j.issn.1008-5971.2023.00.178

Funds：

甘肃省科技计划项目（20JR5RA355）；甘肃省兰州 市人才创新创业项目（2020RCCX0030）

摘要：

主动脉夹层（AD）是一种急性致命的心血管疾病，其发病率和死亡率均较高，可严重威胁患者的生命健康。长链非编码RNA(LncRNA)是一种不能编码蛋白质的RNA，其可广泛参与基因表达过程，且与AD发病机制密切相关。本研究综述了AD的发病机制、AD患者差异表达LncRNA及LncRNA在AD发病机制中的作用，发现LncRNA主要通过调控细胞外基质（ECM）的合成和降解、血管平滑肌细胞（VSMCs）表型转化及促进VSMCs凋亡、血管炎症而参与AD的发生发展，这为寻找AD的可能标志物及治疗靶点提供了新思路。

Abstract：

Aortic dissection (AD) is an acute and fatal cardiovascular disease with high morbidity and mortality, which can seriously threaten the life and health of patients. Long non-coding RNA (LncRNA) is a kind of RNA that can not encode proteins. It can be widely involved in gene expression and is closely related to the pathogenesis of AD. This study reviews the pathogenesis of AD, the differential expression of LncRNA in AD patients and the role of LncRNA in the pathogenesis of AD, and find that LncRNA is mainly involved in the occurrence and development of AD by regulating the synthesis and degradation of extracellular matrix (ECM) , phenotypic transformation of vascular smooth muscle cells (VSMCs) and promoting VSMCs apoptosis and vascular inflammation, which provides new ideas for finding possible markers and therapeutic targets of AD.

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