作者：潘培芬，吴家萱，李春艳，韩剑虹

单位：

昆明医科大学第二附属医院神经内科

Units：

Department of Neurology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650106, China

关键词：

脑出血; 脑微出血; 长链非编码RNA; 病理生理机制; 综述;

Keywords：

Cerebral hemorrhage; Cerebral microbleeds; Long non-coding RNA; Pathophysiological mechanism; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2023.00.160

Funds：

云南省科技厅科技计划项目（202201AT070241）

摘要：

脑微出血（CMBs）是脑小血管病（CSVD）的影像学标志之一，其可影响患者认知功能，增加卒中、痴呆、抗血栓治疗及静脉溶栓后出血转化甚至死亡的风险。CMBs起病隐匿，其发生机制目前尚不明确，其病理过程涉及微血管内皮损伤、氧化应激、血管炎症、血脑屏障破坏等。长链非编码RNA(LncRNA)具有高度的特异性及稳定性，可在多种神经系统疾病中特异表达。近年来研究发现，LncRNA与CMBs的病理过程密切相关，提示LncRNA可能成为早期识别CMBs的生物标志物。本文综述了LncRNA导致CMBs的可能病理生理机制，认为LncRNA参与了CMBs的发生发展，其有望成为CMBs的生物标志物。

Abstract：

Cerebral microbleeds (CMBs) are one of the imaging markers of cerebral small vessel disease (CSVD) , which can affect patients' cognitive function, increase the risk of stroke, dementia, antithrombotic therapy, and intravenous thrombolysisbleeding transformation or even death. The onset of CMBs is hidden, and the pathogenesis is currently unclear. Its pathological processes can be involved microvascular endothelial damage, oxidative stress, vascular inflammation, and bloodbrain barrier damage. Long non-coding RNA (LncRNA) has high specificity and stability, and can be specifically expressed in a variety of nervous system disease. Recent studies have found that LncRNA is closely related to the pathological process of CMBs, suggesting that LncRNA may become a biomarker for early recognition of CMBs. This article reviews the possible pathophysiological mechanisms of LncRNA leading to CMBs, and suggests that LncRNA is involved in the occurrence and development of CMBs, with the potential to become a biomarker for CMBs.

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