作者：李琳，周蕾

单位：

南京医科大学第一附属医院心血管内科

Units：

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

关键词：

心力衰竭; RNA,环状; 心肌肥大; 心肌纤维化; 细胞凋亡;

Keywords：

Heart failure; RNA, circular; Myocardial hypertrophy; Myocardial fibrosis; Apoptosis

CLC：

DOI：

10.12114/j.issn.1008-5971.2023.00.049

Funds：

国家自然科学基金资助项目（81970723）； 伊犁州临床医学研究院研究基金项目（yl2021zd02）；

摘要：

环状RNA是一种单链共价闭合的非编码RNA，在体内稳定存在，具有“海绵效应”，能够调节基因表达，参与转录，编码蛋白质。本文综述了环状RNA在心力衰竭中的作用，指出环状RNA可以通过影响心肌肥大、心肌纤维化、心肌细胞凋亡等病理机制而参与心力衰竭的发生、发展，其有望成为心力衰竭新的治疗靶点。

Abstract：

Circular RNA is a single-stranded covalently closed non-coding RNA, which is stable in vivo and has a "sponge effect" . It can regulate gene expression, participate in transcription, and code protein. This article reviews the role of cyclic RNA in heart failure, and points out that circular RNA can participate in the occurrence and development of heart failure by affecting the pathological mechanisms of cardiac hypertrophy, myocardial fibrosis, and myocardial apoptosis. It is expected to become a new therapeutic target for heart failure.

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