作者：黄润芝，曹长青，李宇宁

单位：

1.兰州大学第一临床医学院2.兰州大学第一医院儿科

Units：

1.The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China2.Department of Pediatrics, the First Hospital of Lanzhou University, Lanzhou 730000, China

关键词：

脑出血; 脑室周围-脑室内出血; 婴儿,早产; 机制; 综述;

Keywords：

Cerebral hemorrhage; Periventricular-intraventricular hemorrhages; Infant, premature; Mechanisms;Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2023.00.057

Funds：

甘肃省教育科技创新项目（2022B-024）；

摘要：

脑室周围-脑室内出血（PVH-IVH）是早产儿常见的一种神经系统疾病，易造成多种并发症及后遗症，且临床诊治效果不佳。明确早产儿发生PVH-IVH的机制是目前该领域研究的热点和重点。大量证据表明，早产儿室管膜下胚胎生发基质（GM）和脑血流（CBF）自动调节系统发育情况与PVH-IVH发生密切相关。本文综述了早产儿发生PVH-IVH的机制，以期增加研究者和临床医生对PVH-IVH的认识，并为临床诊疗提供思路。

Abstract：

Periventricular-intraventricular hemorrhages (PVH-IVH) is a common nervous system disease in prematureinfants, which is easy to cause a variety of complications and sequelae, and has poor clinical diagnosis and treatment effect.Clarifying the mechanism of PVH-IVH in premature infants is the focus of research in this field. A large amount of evidenceshows that the development of the auto-regulating system of subependymal embryonic germinal matrix (GM) and cerebral bloodflow (CBF) in premature infants is closely related to the occurrence of PVH-IVH. This article reviews the mechanism of PVHIVH in premature infants, in order to improve the understanding of researchers and clinicians on PVH-IVH, and provide ideas forclinical diagnosis and treatment.

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