2023 年3 期 第31 卷
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帕金森病与丝裂原活化蛋白激酶信号通路的相关性及中医药干预作用
CorrelationbetweenParkinson'sDiseaseandMAPKSignalingPathwayandtheInterventionEffectofTraditionalChineseMedicine
作者:曹媛媛,孙灵芝
- 单位:
- 1.山东中医药大学2.山东中医药大学附属医院神经内一科
- Units:
- 1.ShandongUniversityofTraditionalChineseMedicine,Jinan250014,China2.DepartmentofNeurology,AffiliatedHospitalofShandongUniversityofTraditionalChineseMedicine,Jinan250014,China
- 关键词:
- 帕金森病; 丝裂原活化蛋白激酶类; p38MAPK信号通路; JNK信号通路; ERK信号通路; 中医药;
- Keywords:
- Parkinson'sdisease;Mitogen-activatedproteinkinaseclass;p38MAPKsignalingpathway;JNKsignalingpathway;ERKsignalingpathway;TraditionalChinesemedicine
- CLC:
- R742.5
- DOI:
- 10.12114/j.issn.1008-5971.2023.00.036
- Funds:
- 山东省自然科学基金面上项目( ZR2021MH180)
摘要:
帕金森病(PD)是一种进行性多系统神经退行性疾病,其中黑质多巴胺能神经元丧失是其重要的病理改变。丝裂原活化蛋白激酶(MAPK)信号通路能调节细胞的生长、分化、凋亡、炎症等多种生理病理过程,近年来其已成为PD机制研究的热点。本文主要综述了PD与MAPK亚家族[p38 MAPK、c-Jun氨基末端激酶(JNK)和细胞外信号调节激酶(ERK)]的相关性及中医药干预作用,以期为PD的诊疗提供新的思路。
Abstract:
Parkinson'sdisease(PD)isaprogressivemultisystemneurodegenerativediseaseinwhichlossofnigrostriataldopaminergicneuronsisanimportantpathologicalchange.Themitogen-activatedproteinkinase(MAPK)signalingpathwayregulatesvariousphysiopathologicalprocessessuchascellgrowth,differentiation,apoptosis,andinflammation,andithasbecomeahotspotforPDmechanismresearchinrecentyears.ThispapermainlyreviewsthecorrelationbetweenPDandMAPKsubfamily[p38MAPK,c-Junamino-terminalkinase(JNK)andextracellularsignal-regulatedkinase(ERK)]andtheinterventionofChinesemedicine,inordertoprovidenewideasforthediagnosisandtreatmentofPD.
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