作者：张曾宇，侯佳豪，吴玲玲，陈思思，陈嘉敏，刘建和

单位：

1.湖南中医药大学中医学院2.湖南中医药大学医学院3.湖南中医药大学中西医结合学院4.湖南中医药大学第一附属医院国家中医心血管病临床医学研究中心分中心

Units：

1.School of Traditional Medicine, Hunan University of Chinese Medicine, Changsha 410208, China 2.Medical School, Hunan University of Chinese Medicine, Changsha 410208, China 3.College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China 4.The First Affiliated Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha 410021, China

关键词：

心肌再灌注损伤; JAK2-STAT3信号通路; 中医药疗法; 综述;

Keywords：

Myocardial reperfusion injury; JAK2-STAT3 signal pathway; Traditional Chinese medicine therapy; Review

CLC：

R 542.2

DOI：

10.12114/j.issn.1008-5971.2023.00.014

Funds：

湖南省中医药科研计划项目（2021011）；国家级大学生创新创业训练计划项目（S202110541045）

摘要：

我国急性ST段抬高型心肌梗死患病率逐年升高，目前多采用再灌注治疗来开通阻塞血管，以减少缺血导致的心肌坏死。而再灌注治疗本身导致的心肌缺血再灌注损伤影响其疗效，这成为临床上治疗心血管疾病不可忽视的问题。近年来关于心肌缺血再灌注损伤发病机制及其治疗思路的研究更加深入且全面，同时JAK2-STAT3信号通路的激活已被证明在心肌损伤过程中具有抗炎、抗氧化应激、调控内质网应激、抗细胞凋亡的作用。中医药因其多环节、多途径、多靶点的治疗优势而受到广泛重视，多种中药单方、复方及中成药可通过JAK2-STAT3信号通路而防治心肌缺血再灌注损伤。本文对JAK2-STAT3信号通路在心肌缺血再灌注损伤中的作用机制及其中医药防治机制进行综述。

Abstract：

The prevalence of acute ST segment elevation myocardial infarction is increasing year by year in China. At present, reperfusion therapy is often used to open blocked vessels to reduce myocardial necrosis caused by ischemia. However, the myocardial ischemia reperfusion injury caused by reperfusion therapy itself effects its efficacy, which has become a problem that can not be ignored in clinical treatment of cardiovascular disease. In recent years, studies on the pathogenesis of myocardial ischemia reperfusion injury and its therapeutic ideas have become more in-depth and comprehensive. Meanwhile, the activation of JAK2-STAT3 signaling pathway has been proved to play an anti-inflammatory, antioxidant stress, endoplasmic reticulum stress regulation, and anti-apoptosis role in the process of myocardial injury. Traditional Chinese medicine (TCM) has been widely valued for its multi-link, multi-pathway and multi-target advantages. A variety of TCM prescriptions, compounds and proprietary medicines can prevent myocardial ischemia reperfusion injury through JAK2-STAT3 signaling pathway. This article reviews the effect mechanism of JAK2-STAT3 signaling pathway in myocardial ischemia reperfusion injury and its TCM prevention and treatment mechanism

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