作者：周曼丽，周霞辉，张宜帆，赵彦禛，高翎薇，简维雄

单位：

1.湖南中医药大学中医学院2.湖南中医药大学国家重点学科中医诊断学实验室湖南省重点实验室

Units：

1.College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China 2.National Key Discipline of TCM Diagnositics/Hunan Provincial Key Laboratory, Hunan University of Chinese Medicine, Changsha 410208, China

关键词：

冠心病; 血瘀证; 心主血脉; 能量代谢; 心脏; 血栓形成; 血小板;

Keywords：

Coronary disease; Blood stasis syndrome; Heart governing blood and vessels; Energy metabolism; Heart; Thrombosis; Blood platelets

CLC：

R 541.4

DOI：

10.12114/j.issn.1008-5971.2023.00.029

Funds：

国家自然科学基金资助项目（81973753）；湖南 省自然科学基金资助项目（2022JJ30433）；湖南省研究生科研 创新项目（CX20220781）；湖南省大学生创新创业训练计划项目 （S202210541116）

摘要：

冠心病是临床常见的严重危害人类健康的重大疾病，血瘀证是最常见、最主要，也是目前研究最多、最深入的中医证型。“心主血脉”是中医“藏象”学说中的重要理论之一，涵盖了心、血、脉三者之间的联系。随着基础医学的日益进步，研究者提出中医理论中的“气”与现代医学中的“线粒体”具有一定的相关性；而中医血瘀证与血小板血栓形成在病理认识方面具有很大的相似性。本文首先回顾了“心主血脉”的理论渊源，然后基于“心主血脉”理论，结合现代医学的研究成果，详细阐述了心主之“心”与能量代谢、心主之“血”与血小板血栓形成的关系，探讨冠心病血瘀证形成的机制。这对今后冠心病血瘀证的实验探究、中西医结合精准施治均具有指导意义。

Abstract：

Coronary heart disease (CHD) is a common major clinical disease that seriously endangers human health. Blood stasis syndrome is the most common, the most important, and also the most studied and the most in-depth type of TCM syndrome. "Heart governing blood and vessels" is one of the important theories in the theory of "Zang Xiang" of TCM, which covers the relationship among heart, blood and vessels. With the increasing progress of basic medicine, researchers have proposed that "Qi" in TCM theory, which has a certain correlation with "mitochondria" in modern medicine; while the blood stasis syndrome of TCM and platelet thrombosis have great similarity in pathological understanding. This paper first reviewed the theoretical origin of "heart governing blood and vessels" , and then based on the theory of "heart governing blood and vessels" , combined with the research results of modern medicine, elaborated the relationship between the "heart" of the heart master and energy metabolism, the "blood" of the heart master and platelet thrombosis, to explore the mechanism of the formation of blood stasis syndrome of CHD. This has guiding significance for the future experimental exploration of blood stasis syndrome of CHD and the precise treatment of integrated traditional Chinese and western medicine

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