作者：秦子雯，王珺，彭召云，师瑞卿，张琪，陈玉娟

单位：

1.250000山东省济南市，山东中医药大学第一临床医学院 2.250000山东省济南市，山东中医药大学第二附属医院呼吸与危重症医学科 通信作者：陈玉娟，E-mail：chenyujuan66@126.com

Units：

1.The First Clinical School of Shandong University of Traditional Chinese Medicine, Jinan 250000, China 2.Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China Corresponding author: CHEN Yujuan, E-mail: chenyujuan66@126.com

关键词：

哮喘; 急性发作期; 穴位疗法; 神经分子机制;

Keywords：

Asthma; Acute exacerbation; Acupoint therapy; Neuromolecular mechanism

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.302

Funds：

山东省中医药科技发展计划项目（2019-0231）

摘要：

支气管哮喘（以下简称哮喘）作为临床发病率较高的慢性呼吸道疾病之一，常通过急性发作的形式对患者的正常生活造成影响。哮喘的发病机制大致可分为气道免疫-炎症机制与神经调节机制，而炎症进展与神经调节亦可相互影响，进而共同参与疾病发展过程。近年来，随着呼吸道神经肽网相关研究的不断丰富，哮喘发病机制的研究重点逐渐由免疫-炎症机制转向神经调节机制。而穴位疗法作为以中医理论为指导的外治法之一，可有效缓解哮喘急性发作期的症状。本文以新兴的神经受体失衡学说为基础，探索穴位疗法治疗支气管哮喘急性发作期的神经分子机制，认为穴位疗法可精准作用于气道相关神经，双向调节相关神经分子的释放与表达，从而控制哮喘发作，在缓解患者病痛的同时提升其生活质量。

Abstract：

【Abstract】　Bronchial asthma (hereinafter referred to as asthma) , as one of the chronic respiratory diseases with high clinical incidence, often affects the normal life of patients in the form of acute attacks. The pathogenesis of asthma can be roughly divided into airway immune-inflammatory mechanism and neuromodulation mechanism, and inflammation progression and neuromodulation can also interact with each other, and then jointly participate in the development of the disease. In recent years, with the continuous enrichment of researches related to the respiratory neuropeptide network, the research focus of asthma pathogenesis has gradually shifted from immune-inflammatory mechanisms to neuromodulation mechanisms. As one of the external treatment methods guided by the theory of traditional Chinese medicine, acupoint therapy can effectively relieve the symptoms of acute asthma attack. Based on the emerging theory of neural receptor imbalance, this paper explores the neuromolecular mechanism of acupoint therapy in the treatment of acute exacerbation of bronchial asthma. It is believed that acupoint therapy can precisely act on the airway-related nerves and regulate the release and expression of related nerve molecules in both directions, thereby controlling the asthma attacks and improving the quality of life of patients while relieving their pain.

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