作者：李冬霞，卫文婷，罗雪，樊佳佳，李得民，贾明月，陈钢，张纾难

单位：

1.北京中医药大学研究生院2.中日友好医院呼吸中心中医肺病科国家呼吸医学中心中国医学科学院呼吸病学研究院国家呼吸系统疾病临床医学研究中心世界卫生组织戒烟与呼吸疾病预防合作中心3.昌平区中医医院4.中国人民大学后勤集团5.中日友好医院体检中心

Units：

Graduate School of Beijing University of Chinese Medicine;Department of Traditional Chinese Medicine for Pulmonary Diseases of Respiratory Medicine Center/National Center for Respiratory Medicine/Institute of Respiratory Medicine of Chinese Academy of Medical Sciences/National Clinical Research Center for Respiratory Diseases/Collaborating Centre for WHO Tobacco Cessation and Respiratory Diseases Prevention, China-Japan Friendship Hospital;Beijing Changping District Traditional Chinese Medicine Hospital;Logistics Group of Renmin University of China;Physical Examination Center, China-Japan Friendship Hospital;

关键词：

多发性肺结节; 孤立性肺结节; 乳腺结节; 甲状腺结节; 肾囊肿; 胆囊结石; 结节体质; 北京; 影响因素分析;

Keywords：

Multiple pulmonary nodules;Solitary pulmonary nodules;Breast nodules;Thyroid nodules;Renal cysts;Cholecystolithiasis;Nodular constitution;Beijing;Root cause analysis;

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.331

Funds：

国家自然科学基金资助项目（82104760）； 中日友好医院“菁英计划”人才培育工程（ZRJY2021-GG06）； 国家区域（专科）中医诊疗中心建设（中医肺病）项目（2019-zx-004）；

摘要：

目的 分析北京市某三甲医院体检人群结节体质检出情况及其影响因素。方法 回顾性选取2020年12月至2021年5月在中日友好医院体检中心行健康体检者10 277例为研究对象。收集体检者一般资料、血清肿瘤标志物、影像学检查结果。将影像学检查报告提示有3种及以上结节或囊肿者纳入结节体质组，其余纳入非结节体质组。采用多因素Logistic回归分析探讨结节体质的影响因素。结果 10 277例体检者中，男5 267例，女5 010例；2 094例（20.38%）为结节体质。结节体质组女性占比、甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类抗原199(CA199)、总前列腺特异抗原（TPSA）、胃泌素释放肽前体（Pro-GRP）、鳞状上皮细胞癌抗原（SCC）、细胞角质蛋白19片段抗原21-1(CYFRA21-1)高于非结节体质组，年龄大于非结节体质组，糖类抗原125(CA125)低于非结节体质组（P<0.05）。多因素Logistic回归分析结果显示，性别[OR=1.607,95%CI(1.452,1.779)]、年龄[OR=1.050,95%CI(1.045,1.054)]是结节体质的影响因素（P<0.05）。结论 体检人群结节体质检出率为20.38%，且女性、年龄增长是结节体质的危险因素。

Abstract：

Objective To explore the detection and influencing factors of nodular constitution in physical examination population of a tertiary A hospital in Beijing. Methods A total of 10 277 persons who underwent physical examination in the Physical Examination Center of China-Japan Friendship Hospital from December 2020 to May 2021 were retrospectively selected as the study objects. General data, serum tumor markers and imaging results were collected. Persons with three or more nodules or cysts reported by imaging examination were included in the nodular constitution group, and the rest persons were included in the non-nodular constitution group. Multivariate Logistic regression analysis was used to explore the influencing factors of nodular constitution. Results Among 10 277 physical examinees, 5 267 were male and 5 010 were female; 2 094 cases（20.38%） had nodular constitution. The proportion of women, alpha fetoprotein（AFP）, carcinoembryonic antigen（CEA）, carbohydrate antigen 199（CA199）, total prostate specific antigen（TPSA）, gastrin releasing peptide precursor（Pro-GRP）, squamous cell carcinoma antigen（SCC）, cyto-keratin 19 fragment antigen 21-1（CYFRA21-1） in the nodular constitution group were higher than those in the non-nodular constitution group, the age was older than that in the non-nodular constitution group, and the carbohydrate antigen 125（CA125） was lower than that in the non-nodular constitution group（P < 0.05）. Multivariate Logistic regression analysis showed that gender [OR=1.607, 95%CI（1.452, 1.779） ] and age [OR=1.050, 95%CI（1.045, 1.054） ] were influencing factors of nodular constitution（P < 0.05）. Conclusion The detection rate of nodular constitution in physical examination population is 20.38%, and women and the increase of age are risk factors of nodular constitution.

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