作者：李晓晓，白艳杰，王岩，张雍闯，陈丽敏，陈淑颖

单位：

1.450046河南省郑州市，河南中医药大学康复医学院　 2.450000河南省郑州市，河南中医药大学第一附属医院康复中心 通信作者：白艳杰，E-mail：baiyj66@126.com

Units：

1.School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China 2.Rehabilitation Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China Corresponding author: BAI Yanjie, E-mail: baiyj66@126.com

关键词：

血管性痴呆; 脑血流量; 侧支循环; 认知障碍;

Keywords：

Dementia, vascular; Cerebral blood flow; Collateral circulation; Cognitive impairment

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.278

Funds：

国家重点研发计划项目（2018YFC1706004）；河南 省中医药科学研究专项课题（20-21ZY1009）；河南省卫生健康委国 家中医临床研究基地科研专项重点项目（2022JDZX005）；河南省 重点研发与推广专项（222102310529）；河南省中医药拔尖人才培养 项目（CZ0237-08）

摘要：

血管性痴呆(VD)是一种常见的痴呆类型，其发病率逐年上升，以进行性记忆丧失、认知功能下降和言语功能受损为主要表现，可严重影响患者的生活质量。充足的脑血流量(CBF)是维持大脑结构完整性和正常功能的首要条件，而CBF减少导致的神经元凋亡通常被认为是造成VD的重要原因。侧支循环是CBF的一种补偿机制，为血液到达缺血组织提供了一条替代的血管通路，其与VD存在密切联系。本文总结了侧支循环分级及其代偿特征，阐述了侧支循环与VD之间的关系，并强调改善侧支循环可能是减缓VD发生发展的潜在策略。

Abstract：

【Abstract】 Vascular dementia (VD) is a common type of dementia. Its incidence rate is increasing year by year. It is mainly manifested by progressive memory loss, cognitive decline and impaired speech function, which seriously affect the quality of life of patients. Adequate cerebral blood flow (CBF) is the primary condition for maintaining brain structural integrity and normal function, and neuronal apoptosis caused by decreased CBF is usually considered to be an important cause of VD. Collateral circulation is a compensation mechanism of CBF, which provides an alternative vascular pathway for blood to reach ischemic tissue. It is closely related to VD. This paper summarizes the classification of collateral circulation and its compensatory characteristics, expounds the relationship between collateral circulation and VD, and emphasizes that improving collateral circulation may be a potential strategy to slow down the progress of VD.

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