作者：张红红，王利军，杨世倩，龙春欢，魏欣欣

单位：

050000河北省石家庄市人民医院感染科 呼吸二科 通信作者：王利军，E-mail：304473007@qq.com

Units：

Department of Infectious Disease/Department of Respiratory, Shijiazhuang People's Hospital, Shijiazhuang 050000, China Corresponding author: WANG Lijun, E-mail: 304473007@qq.com

关键词：

肺炎; 重症肺炎; 可溶性髓样细胞触发受体1; 白介素17; 肠道菌群;

Keywords：

Pneumonia; Severe pneumonia; Soluble triggering receptor expressed on myeloid cell-1; Interleukin-17; Intestinal flora

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.279

Funds：

石家庄市科学技术研究与发展计划项目（211460803）

摘要：

目的 分析重症肺炎患者血清可溶性髓样细胞触发受体1(sTREM-1)、白介素(IL)-17水平与肠道菌群的相关性。方法 选取2021年10月至2022年7月石家庄市人民医院收治的重症肺炎患者100例作为观察组。选取同期石家庄市人民医院收治的普通肺炎患者100例作为对照组。比较两组血清sTREM-1、IL-17水平及肠道菌群(大肠埃希菌、肠球菌、拟杆菌、双歧杆菌、乳酸杆菌)数量，采用Spearman秩相关分析、多元线性回归分析探讨观察组血清sTREM-1、IL-17水平与肠道菌群数量的相关性。结果 观察组血清sTREM-1、IL-17水平高于对照组(P<0.05)。观察组大肠埃希菌、肠球菌数量多于对照组，拟杆菌、双歧杆菌、乳酸杆菌数量少于对照组(P<0.05)。Spearman秩相关分析结果显示，观察组血清sTREM-1、IL-17水平与大肠埃希菌、肠球菌数量呈正相关，与拟杆菌、双歧杆菌、乳酸杆菌数量呈负相关(P<0.05)。多元线性回归分析结果显示，观察组血清sTREM-1、IL-17水平与大肠埃希菌、肠球菌数量呈独立正相关，与拟杆菌、双歧杆菌、乳酸杆菌数量呈独立负相关(P<0.05)。结论 重症肺炎患者血清sTREM-1、IL-17水平随着大肠埃希菌、肠球菌数量增多及拟杆菌、双歧杆菌、乳酸杆菌数量减少而升高。

Abstract：

【Abstract】　Objective To explore the relationship between serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) , interleukin (IL) - 17 levels and intestinal flora in patients with severe pneumonia. Methods A total of 100 patients with severe pneumonia admitted to Shijiazhuang People's Hospital from October 2021 to July 2022 were selected as the observation group, and 100 patients with common pneumonia admitted to Shijiazhuang People's Hospital during the same period were selected as the control group. The levels of serum sTREM-1 and IL-17 and the number of intestinal flora (Escherichia coli, Enterococcus, Bacteroides, Bifidobacterium and Lactobacillus) were compared between the two groups. Spearman rank correlation analysis and multiple linear regression analysis were used to explore the correlation between the levels of serum sTREM-1 and IL-17 and the number of intestinal flora in the observation group. Results The levels of serum sTREM-1 and IL-17 in the observation group were higher than those in the control group (P < 0.05) . The number of Escherichia coli and Enterococcus in the observation group was more than that in the control group, and the number of Bacteroides, Bifidobacterium and Lactobacillus was less than that in the control group (P < 0.05) . Spearman rank correlation analysis showed that, in the observation group, the levels of serum sTREM-1 and IL-17 were positively correlated with the number of Escherichia coli and Enterococcus, and negatively correlated with the number of Bacteroides, Bifidobacterium and Lactobacillus (P < 0.05) . The results of multiple linear regression analysis showed that, in the observation group, the levels of serum sTREM-1 and IL-17 were independently positively correlated with the number of Escherichia coli and Enterococcus, and independently negatively correlated with the number of Bacteroidetes, Bifidobacteria and Lactobacillus (P < 0.05) . Conclusion The levels of serum sTREM-1 and IL-17 increased with the increase of Escherichia coli and Enterococcus and the decrease of Bacteroidetes, Bifidobacteria and Lactobacillus in patients with severe pneumonia.

ReferenceList：