作者：刘红艳，高笑宇，李媛，孙德俊

单位：

010017内蒙古自治区呼和浩特市，内蒙古自治区人民医院国家卫健委慢阻肺诊治重点实验室 内蒙古自治区呼吸疾病重点实验室

Units：

National Health Commission Key Laboratory of Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease/InnerMongolia Autonomous Region Key Laboratory of Respiratory Diseases, Inner Mongolia People's Hospital, Hohhot 010017, China

关键词：

吸烟；基因簇；CHRNA5-A3-B4基因簇；烟碱型乙酰胆碱受体；综述

Keywords：

Smoking; Gene clusters; CHRNA5-A3-B4 gene cluster; Nicotinic acetylcholine receptor; Review

CLC：

　R 163　

DOI：

10.12114/j.issn.1008-5971.2022.00.230

Funds：

国家自然科学基金资助项目（ 8 1 9 6 0 0 1 3 ） ；中国医学科学院中央级公益性科研院所基本科研业务费项目（ 2 0 1 9 P T 3 5 0 0 0 1 ） ； 中央引导地方科技发展资金项目（2020ZY0030）

摘要：

烟碱型乙酰胆碱受体（nAChRs）是一种配体门控离子通道受体，可与乙酰胆碱、尼古丁等物质结合而释放多种神经递质，进而参与物质的合成与分泌。CHRNA5-A3-B4基因簇位于nAChRs 15q25.1染色体上，可编码α5、α3、β4亚基，其可相互协调，共同调控基因位点，增强基因表达，影响生物性状。越来越多的研究发现，多种因素均可对吸烟行为产生影响，其中全基因组关联研究（GWASs）已明确CHRNA5-A3-B4基因簇与尼古丁依赖性和吸烟量具有强关联性。本文就CHRNA5-A3-B4基因簇与吸烟行为的相关性进行综述，以期为戒烟药物新靶点的开发和烟草相关疾病的基因干预治疗提供新思路。

Abstract：

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channel receptors that can bind toacetylcholine, nicotine and other substances to release a variety of neurotransmitters, and then participate in the synthesis andsecretion of substances. The CHRNA5-A3-B4 gene cluster is located on the nAChRs 15q25.1 chromosome and can encodeα5, α3, and β4 subunits, which can coordinate with each other to jointly regulate gene loci, enhance gene expression, andaffect biological traits. More and more studies have found that various factors can affect smoking behavior, among which genomewideassociation studies (GWASs) have confirmed that the CHRNA5-A3-B4 gene cluster is strongly associated with nicotinedependence and smoking. This article reviews the correlation between the CHRNA5-A3-B4 gene cluster and smoking behavior,in order to provide new ideas for the development of new targets for smoking cessation drugs and gene intervention therapy fortobacco-related diseases.

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