作者：戚萌1，刘璐2，杨淑梅2，兀威3，梁楠1，史鑫1

单位：

1.710068陕西省西安市，西安医学院2.710068陕西省西安市，陕西省人民医院呼吸与危重症一科3.710038陕西省西安市，西安医学院第二附属医院呼吸内科

Units：

1.Xi'an Medical University, Xi'an 710068, China2.Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an 710068, China3.Department of Respiratory, the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, China

关键词：

糖尿病；肺损伤；肺疾病；降糖药物；综述

Keywords：

Diabetes mellitus; Lung injury; Lung disease; Hypoglycemic drugs; Review

CLC：

R 587.1　R 563　

DOI：

10.12114/j.issn.1008-5971.2022.00.246

Funds：

陕西省重点研发计划项目（2020ZDLSF01-06）

摘要：

　肺脏具有丰富的结缔组织和微血管循环，故易受到高血糖的影响。目前，肺功能降低与糖尿病的关系尚未完全明确。笔者分析国内外相关文献发现，糖尿病致肺损伤的可能病理生理机制包括胰岛素抵抗、低级别炎症、微血管病变、累及呼吸肌的神经病变及蛋白质非酶糖基化；此外，除胰岛素之外的大多数降糖药被证实可以通过减轻炎症、降低气道高反应性、促进癌细胞凋亡等机制而对肺疾病产生积极影响，而胰岛素可能对肺疾病产生消极影响，这对糖尿病合并肺疾病患者的治疗具有一定参考价值。

Abstract：

Because of its rich connective tissue and microvascular circulation, the lung is susceptible to the effectsof hyperglycemia. At present, the relationship between pulmonary function reduction and diabetes mellitus has not beenfully clarified. By analyzing the relevant literature at home and abroad, the author found that the possible pathophysiologicalmechanisms of diabetes mellitus-induced lung injury include insulin resistance, low-grade inflammation, microvasculardisease, neuropathy involving the respiratory muscle and protein non-enzymatic glycosylation. In addition, most hypoglycemicagents except insulin have been proved to have a positive impact on lung diseases by reducing inflammation, reducing airwayhyperresponsiveness, and promoting apoptosis of cancer cells, while insulin may have a negative impact on lung diseases, whichhas a certain reference value for the treatment of diabetes mellitus patients complicated with lung diseases.

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