作者：梁彤1，林玥2，任明2

单位：

1.810000青海省西宁市，青海大学 　2.810000青海省西宁市，青海大学附属医院心血管内科

Units：

1.Qinghai University, Xining 810000, China2.Department of Cardiology, Qinghai University Affiliated Hospital, Xining 810000, China

关键词：

高血压；肠道菌群；代谢产物；综述

Keywords：

Hypertention; Intestinal flora; Metabolite; Review

CLC：

R 544.1　

DOI：

10.12114/j.issn.1008-5971.2022.00.220

Funds：

青海省临床医学研究中心项目（2019-SF-L2）；青海大学附属医院中青年科研基金项目（ASRF-2021-YB-06）

摘要：

研究表明，肠道菌群参与了高血压的发生、发展过程，关于其机制的研究目前包括代谢产物对血压的影响、微生物群-肠道-大脑轴及免疫因素、血管内皮损伤等方面，其中肠道菌群代谢产物（包括短链脂肪酸、胆汁酸、脂肪酸等）与高血压的关系研究较为充分。本文主要综述了肠道菌群代谢产物与高血压的关系，以期为高血压的预防和治疗提供理论基础和新的治疗思路。

Abstract：

Studies have shown that intestinal flora is involved in the occurrence and development of hypertension. The research on its mechanism currently includes the effects of metabolites on blood pressure, microbial flora-intestinal-brain axis and immune factors, and vascular endothelial injury. Among them, the relationship between intestinal flora metabolites (including short-chain fatty acids, bile acids, fatty acids, etc. ) and hypertension is relatively sufficient. This paper reviews the relationship between intestinal flora metabolites and hypertension, in order to provide theoretical basis and new treatment ideas for theprevention and treatment of hypertension.

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