作者：王颖1，刘健2，云春梅1，高笑宇1

单位：

1.010017内蒙古自治区呼和浩特市，内蒙古自治区人民医院呼吸与危重症医学科 国家卫健委慢阻肺诊治重点实验室 内蒙古自治区呼吸疾病重点实验室　2.010050内蒙古自治区呼和浩特市，内蒙古医科大学附属医院血液科

Units：

1.Department of Pulmonary and Critical Care Medicine, Inner Mongolia People's Hospital/National Key Laboratory forDiagnosis and Treatment of Chronic Obstructive Pulmonary Disease/Inner Mongolia Autonomous Region Key Laboratory ofRespiratory Diseases, Huhhot 010017, China2.Department of Hematology, the Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, China

关键词：

支气管哮喘；2型固有淋巴细胞；气道炎症表型；综述

Keywords：

Bronchial asthma; Type 2 innate lymphoid cells; Airway inflammation phenotypes; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.174

Funds：

内蒙古自然科学基金面上项目（2021MS08165，2021MS08112）；内蒙古自治区科技计划项目（201802161）；内蒙古自治区人民医院院内重大基金项目（201703）；内蒙古自治区人民医院博士科研启动资金（2019BS08）

摘要：

2型固有淋巴细胞（ILC2s）是一类非B淋巴细胞、非T淋巴细胞的新型淋巴细胞，能够独立或与Th2细胞共同参与支气管哮喘（以下简称哮喘）的发生。ILC2s主要与过敏性哮喘的发生及其急性发作相关。随着研究的深入，发现不同气道炎症表型哮喘患者的发病机制不同，使其具有不同的临床特点及治疗方法。本文主要介绍了ILC2s起源、哮喘的气道炎症表型及ILC2s在不同气道炎症表型哮喘中的作用，从而得出ILC2s在不同气道炎症表型哮喘中发挥不同作用，因而研究其具体机制可进一步为哮喘治疗提供新方向、新思路。

Abstract：

Type 2 innate lymphoid cells (ILC2s) is a new type of non-B lymphocyte cell and non-T lymphocyte celllymphoid cells, which can participate in the occurrence of bronchial asthma independently or together with Th2 cells. ILC2s ismainly related to the occurrence and acute attack of allergic bronchial asthma. With the deepening of research, the pathogenesisof bronchial asthma patients with different airway inflammation phenotypes is different, which makes them have differentclinical characteristics and treatment methods. This article mainly introduces the ILC2s origin, airway inflammation phenotypesof bronchial asthma, and the role of ILC2s in different airway inflammation phenotypes of bronchial asthma. Therefore, it isconcluded that ILC2s plays different roles in different airway inflammation phenotypes of bronchial asthma. Studying its specificmechanism can further provide new directions and new ideas for the treatment of bronchial asthma.

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