作者：刘长兴，郭心怡，张雷雷，常翔

单位：

1.712046陕西省咸阳市，陕西中医药大学 2.710016陕西省西安市中医医院脑病科 通信作者：常翔，E-mail：155276065@qq.com

Units：

1.Shaanxi University of Chinese Medicine, Xianyang 712046, China 2.Encephalopathy Department, Xi'an Hospital of Traditional Chinese Medicine, Xi'an 710016, China Corresponding author: CHANG Xiang, E-mail: 155276065@qq.com

关键词：

缺血性脑卒中; 铁死亡; 中医药疗法; 综述;

Keywords：

Ischemic stroke; Ferroptosis; Traditional Chinese medicine therapy; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.185

Funds：

第六批全国老中医药专家学术经验继承工作项目（国中医药人教发〔2017〕29号）

摘要：

缺血性脑卒中的发病率、死亡率和致残率均较高,且其发病机制复杂多样。铁死亡是在神经元损伤中发现的一种新型非凋亡性细胞死亡方式,其特点是铁依赖性和过度积累的脂质过氧化物。铁死亡过程中产生的过量脂质活性氧最终导致细胞氧化死亡。中医药具有多靶点、多渠道作用的优势,对铁死亡具有一定的治疗价值。本文简述了铁死亡的特点、发生机制以及缺血性脑卒中患者发生铁死亡的机制,并总结了近年来中医药通过干预铁死亡治疗缺血性脑卒中相关研究进展,以期为缺血性脑卒中患者铁死亡的靶点治疗提供参考。

Abstract：

【Abstract】 The incidence rate, mortality rate and disability rate of ischemic stroke are high, and the pathogenesisof ischemic stroke is complex and diverse. Ferroptosis is a novel non-apoptotic mode of cell death found in neuronal injurycharacterized by iron-dependent and excessive accumulation of lipid peroxides. The excess lipid reactive oxygen speciesgenerated during ferroptosis ultimately leads to oxidative cell death. Traditional Chinese medicine has the advantages of multitarget and multi-channel effects, and has certain therapeutic value for ferroptosis. This paper briefly describes the characteristics,mechanism of ferroptosis and the mechanism of ferroptosis in patients with ischemic stroke, and summarizes the research progressof traditional Chinese medicine in the treatment of ischemic stroke by intervening ferroptosis in recent years, in order to providereference for the target treatment of ferroptosis in patients with ischemic stroke.

ReferenceList：