作者：刘美洋，孙佳伟，崔志峰，宫小薇，袁雅冬

单位：

050000河北省石家庄市，河北医科大学第二医院呼吸与危重症医学科 通信作者：袁雅冬，E-mail：yuanyd1108@163.com

Units：

Department of Respiratory and Critical Care Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang 050000,China Corresponding author: YUAN Yadong, E-mail: yuanyd1108@163.com

关键词：

肺动脉高压; TANK结合激酶1; 免疫,先天; 代谢重编程; 细胞外基质; 综述;

Keywords：

Pulmonary arterial hypertension; TANK-binding kinase 1; Immunity, innate; Metabolic reprogramming;Extracellular matrix; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.187

Funds：

河北省重点研发计划项目（21377701D）

摘要：

肺动脉高压(PH)的发生、发展是多种因素相互作用的结果,其病理过程复杂。近年来大量研究证实,巨噬细胞中损伤相关分子模式(DAMP)相关先天免疫、巨噬细胞代谢以及肺血管系统细胞外基质(ECM)重塑均在PH的病理生理过程中发挥了重要作用,而TANK结合激酶1(TBK1)在以上过程中发挥了不可替代的作用。本文立足于TBK1,综述了TBK1的结构与活化机制、巨噬细胞与PH的关系及TBK1在PH患者巨噬细胞DAMP相关先天免疫、巨噬细胞代谢、肺血管系统ECM重塑中的作用,以期为PH的治疗提供新的方向与靶点。

Abstract：

【Abstract】　The occurrence and development of pulmonary hypertension (PH) is the result of the interaction of manyfactors, and its pathological process is complex. In recent years, a large number of studies have confirmed that innate immunityrelated to damage-associated molecular patterns (DAMP) in macrophages, macrophage metabolism and extracellular matrix (ECM)remodeling of pulmonary vascular system play an important role in the pathophysiological process of PH, and TANK-bindingkinase 1 (TBK1) plays an irreplaceable role in the above processes. Based on TBK1, this paper reviews the structure and activationmechanism of TBK1, the relationship between macrophages and PH, and the role of TBK1 in DAMP-related innate immunity ofmacrophages, macrophage metabolism, and ECM remodeling of pulmonary vascular system in PH patients, in order to provide newdirections and targets for the treatment of PH.

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