作者：冯佳欣1，卢成志2

单位：

1.300000天津市，天津医科大学第一中心临床学院 天津市第一中心医院　 2.300000天津市第一中心医院心内科

Units：

1.The First Central Clinical School, Tianjin Medical University/Tianjin First Center Hospital, Tianjin 300000, China 2.Department of Cardiology, Tianjin First Center Hospital, Tianjin 300000, China

关键词：

心血管疾病；内皮细胞；细胞衰老；钠-葡萄糖共转运蛋白2抑制剂；氧化应激；一氧化氮；综述

Keywords：

Cardiovascular diseases; Endothelial cell; Cellular senescence; Sodium-glucose transporter 2 inhibitors;Oxidative stress; Nitric oxide; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.177

Funds：

国家自然科学基金资助项目（81970303）

摘要：

内皮细胞衰老与慢性心血管疾病密切相关。活性氧（ROS）增加与一氧化氮（NO）减少可导致内皮功能损伤，进而推动内皮细胞衰老进程。钠-葡萄糖共转运蛋白2（SGLT2）抑制剂可能是近年来治疗衰老相关疾病最有前途的药物之一。本文通过分析、总结相关文献发现，SGLT2抑制剂抗内皮细胞衰老的主要机制是平衡NO及减轻氧化应激，涉及的信号通路可能有PI3K/Akt/eNOS、AMPK/Akt/eNOS、AMPK、SIRT1、胰岛素样生长因子1（IGF-1）、mTOR、Akt/FOXO、胰岛素/IGF-1/FOXO等，这将为慢性心血管疾病提供新的治疗靶点。

Abstract：

【Abstract】　Endothelial cell senescence is closely related to chronic cardiovascular diseases. The increase of reactiveoxygen species (ROS) and the decrease of nitric oxide (NO) can lead to endothelial cell damage, and then promote the process ofendothelial cell senescence. Sodium glucose cotransporter 2 (SGLT2) inhibitors may be one of the most promising drugs for thetreatment of aging related diseases in recent years. Based on the analysis and summary of relevant literature, it is found that themain mechanism of SGLT2 inhibitor against endothelial cell senescence is to balance NO and reduce oxidative stress. The signalpathways involved may include PI3K/Akt/eNOS, AMPK/Akt/eNOS, AMPK, SIRT1, insulin-like growth factor 1 (IGF-1) , mTOR,Akt/FOXO, insulin/IGF-1/FOXO, etc., which will provide new therapeutic targets for chronic cardiovascular diseases.

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