作者：米文静，孙灵芝

单位：

1.250014 山东省济南市，山东中医药大学 2.250014 山东省济南市，山东中医药大学附属医院神经内一科 通信作者：孙灵芝，E-mail：slzsunny@126.com

Units：

1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China 2.Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China Corresponding author: SUN Lingzhi, E-mail: slzsunny@126.com

关键词：

帕金森病; 线粒体功能障碍; 线粒体自噬; 线粒体复合物Ⅰ; 氧化应激; α-突触核蛋白; 中医药疗法;

Keywords：

Parkinson's disease; Mitochondrial dysfunction; Mitochondrial autophagy; Mitochondrial complex Ⅰ;Oxidative stress; α-syn uclein; Traditional Chinese medicine therapy

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.150

Funds：

山东省自然科学基金面上项目（ZR2021MH180）

摘要：

帕金森病是一种慢性进展性神经系统退行性疾病,黑质多巴胺神经元的变性死亡是其主要病理特征,但引起这一病理特征的具体机制尚不明确。线粒体是细胞的能量“工厂”,近年来线粒体功能障碍与帕金森病的关系成为研究热点。本文将从线粒体自噬障碍、线粒体复合物Ⅰ损伤、氧化应激以及减少α-突触核蛋白聚集等方面分析线粒体功能障碍与帕金森病的关系以及中医药对其干预作用,以期为帕金森病的中西医诊断与治疗提供新的策略。

Abstract：

【Abstract】 Parkinson's disease is a chronic progressive neurodegenerative disease, and degenerative death ofsubstantia nigra dopamine neurons is its main pathological feature. But the specific mechanism that causes this pathologicalchange is unclear. Mitochondria are the energy "factory" of cells, and in recent years, the relationship between mitochondrialdysfunction and Parkinson's disease has become a hot topic of research. In this paper, we will analyze the correlation betweenmitochondrial dysfunction and Parkinson's disease from the aspects of mitochondrial autophagy, mitochondrial complex Ⅰ injury,oxidative stress and α-synuclein aggregation, as well as the intervention effect of traditional Chinese medicine, in order to providea new strategy for the diagnosis and treatment of Parkinson's disease by traditional Chinese and western medicine.

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