作者：朱浩东，陈嘉伟，肖宜超

单位：

1.410011湖南省长沙市，中南大学湘雅二医院心血管内科 2.410006湖南省长沙市，中南大学湘雅医学院 通信作者：肖宜超，E-mail：yichaoxiao@csu.edu.cn

Units：

1.Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha 410011, China 2.Xiangya School of Medicine, Central South University, Changsha 410006, China Corresponding author: XIAO Yichao, E-mail: yichaoxiao@csu.edu.cn

关键词：

心房颤动; 肠道菌群; 机制; 综述;

Keywords：

Atrial fibrillation; Intestinal flora; Mechanism; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.082

Funds：

摘要：

心房颤动是临床最常见的持续性心律失常,其发病机制复杂。近年来肠道菌群对心房颤动的影响受到了临床关注。本文主要分析了肠道菌群与心房颤动的关系及可能机制,发现肠道菌群失调对心房颤动的调节作用主要由肠道菌群代谢产物介导,其中脂多糖(LPS)和氧化三甲胺(TMAO)可激活NLRP3-IL-1β-L型钙通道通路和/或调控心脏自主神经活性并促进心房重构,进而促进心房颤动的发生发展。虽然目前对肠道菌群影响心房颤动的认识较为局限,但现有研究提示LPS和TMAO等肠道菌群代谢产物可能成为心房颤动治疗的新靶点。

Abstract：

【Abstract】 Atrial fibrillation with a complicated pathogenesis, is the most common clinical persistent arrhythmia.In recent years, the effect of intestinal flora on atrial fibrillation has attracted clinical attention. This paper mainly analyzedthe relationship between intestinal flora and atrial fibrillation and its possible mechanism, and found that, the way microbiotadysbiosis regulating atrial fibrillation is thought to be mainly mediated by microbiota metabolites. Among them, lipopolysaccharide(LPS) and trimethylamine-N-oxide (TMAO) may mediate atrial remodeling through inflammatory pathways such as "NLRP3-IL-1β-L-type calcium channel" pathway and/or through its effect on cardiac autonomic nervous system, eventually initiatingand promoting atrial fibrillation. Although the current understanding of effect of intestinal flora on atrial fibrillation is relativelylimited, existing studies have already suggested that key substances such as LPS and TMAO may become new targets for atrialfibrillation treatment.

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