作者：冉启娟，李芳伟，万毅新

单位：

1.730030甘肃省兰州市，兰州大学第二临床医学院 2.730030甘肃省兰州市，兰州大学第二医院呼吸内科 通信作者：万毅新，E-mail：1019374153@qq.com

Units：

1.Lanzhou University Second Hospital, Lanzhou 730030, China2.Department of Respiratory Medicine, Lanzhou University Second Hospital, Lanzhou 730030, ChinaCorresponding author: WAN Yixin, E-mail: 1019374153@qq.com

关键词：

过敏性支气管肺曲霉菌病; 发病机制; 诊断; 辅助检查; 综述;

Keywords：

Allergic bronchopulmonary aspergillosis; Pathogenesis; Diagnosis; Supplementary examinations; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.065

Funds：

国家自然科学基金资助项目（81960014）

摘要：

过敏性支气管肺曲霉菌病(ABPA)为支气管哮喘常见合并症,其致病菌为曲霉菌,近年其全球发病率呈上升趋势。本文结合既往文献针对ABPA的发病机制、诊断及辅助检查进行综述,结果发现ABPA发病机制主要与遗传因素、免疫缺陷有关;其临床表现与呼吸系统疾病相似,容易混淆,临床误诊率较高;Rosenberg标准、Greenberger标准、ISHAM标准2013版、ISHAM标准2016版及Asano标准是ABPA的诊断标准,但各诊断标准并不统一;ABPA的实验室检查以烟曲霉菌特异性IgE和IgG检查为主,影像学检查首选高分辨率CT。

Abstract：

【Abstract】 Allergic bronchopulmonary aspergillosis (ABPA) is a common complication of bronchial asthma.Itspathogen is aspergillus，and the incidence of global is increasing in recent years. This article reviews the pathogenesis, diagnosisand auxiliary examination of ABPA in combination with previous literature, and finds that the pathogenesis of ABPA is mainlyrelated to genetic factors and immunodeficiency. Its clinical manifestations overlap with respiratory diseases and it is easy to beconfused, leading to a highe misdiagnosis of clinical practice. Rosenberg criteria, Greenberg criteria, ISHAM criteria 2013 version,ISHAM criteria 2016 version and Asano criteria are the diagnostic criteria of ABPA, but the diagnostic criteria are not unification.Laboratory examinations are mainly based on aspergillus fumigatus-specific IgE and IgG examinations. High resolution CT is thefirst choice for imaging examination.

ReferenceList：