作者：杨洁，区腾飞，杨新光

单位：

1.510260 广东省广州市，广州医科大学附属第二医院神经内科2.528000 广东省佛山市第二人民医院神经内科通信作者：杨新光，E-mail：yangxinguang0926@163.com

Units：

1.Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China2.Department of Neurology, Foshan Second People's Hospital, Foshan 528000, ChinaCorresponding author: YANG Xinguang, E-mail: yangxinguang0926@163.com

关键词：

脑梗死; 机械取栓; 血栓; 综述;

Keywords：

Brain infarction; Mechanical thrombectomy; Thrombus; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.007

Funds：

国家自然科学基金青年科学基金项目（81801304）；广东省自然科学基金项目（粤科规财字［2017］105 号）；广州市卫生健康科技项目（20211A011081）

摘要：

急性脑梗死是威胁我国人民健康的重大疾病,其致死率及致残率均较高,造成了沉重的社会负担。及时开通导致梗死的责任血管以恢复脑灌注是治疗该病的关键。机械取栓技术的应用使得患者的血栓组织能够被获取并得到研究。本文介绍了近年来通过机械取栓术获取的血栓的相关研究发现,以纤维蛋白为主的血栓是造成取栓困难的重要组织学原因,影像学方法可以在术前评估血栓特征。这些发现提示临床工作者可以积极开发新型血栓取出装置用于处理难治性血栓,并有必要探索精确便捷的血栓特征影像学评价方法,从而提高机械取栓疗效。

Abstract：

【Abstract】 Acute cerebral infarction is a major disease threatening people's health in China. Its mortality and disabilityrate are high, resulting in a heavy social burden. Timely recanclizing the responsible vessels leading to infarction to restorecerebral perfusion is the key to the treatment of the disease. The application of mechanical thrombectomy technology enablesthe thrombus tissue of patients to be obtained and studied. This paper introduces the related studies of thrombus obtained bymechanical thrombectomy in recent years. It is found that thrombus dominated by fibrin is an important histological reason forthe difficulty of thrombus removal, and imaging methods can evaluate the characteristics of thrombus before operation. Thesefindings suggest that clinicians can actively develop new thrombus removal devices for the treatment of refractory thrombus, andit is necessary to explore accurate and convenient imaging evaluation methods for thrombus characteristics, so as to improve thecurative effect of mechanical thrombectomy.

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