作者：张星1 ，姜萍 2 ，杨金龙 2 ，张永健 1 ，王文婷 1 ，韩晓伟 1 ，李晓 2

单位：

1.250014 山东省济南市，山东中医药大学2.250011 山东省济南市，山东中医药大学附属医院

Units：

1.Shandong University of Traditional Chinese Medicine，Jinan 250014，China2.Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250011，China

关键词：

肥胖症；感染性疾病；病毒；新型冠状病毒肺炎；严重急性呼吸综合征冠状病毒 2

Keywords：

Obesity；Infectious diseases；Viruses；COVID-19；SARS-CoV-2

CLC：

DOI：

10.12114/j.issn.1008-5971.2021.00.024

Funds：

国家自然科学基金资助项目（8187151150）；国家自然科学基金青年科学基金资助项目（8180151244）

摘要：

新型冠状病毒肺炎（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的呼吸系统传染病，具有传染性强、潜伏期长的特点。目前，COVID-19 已经扩散至全球多个国家，且感染人数仍在不断攀升。对阳性患者进行隔离和减少人群聚集是 COVID-19 的主要预防办法，然而针对 COVID-19 的特效药仍在探索中。肥胖与病毒感染性疾病的关系在既往研究中已经得到证实，包括肥胖者发生病毒感染性疾病的风险较高、肥胖的病毒感染性疾病患者预后更差。本文综述了肥胖者病毒感染性疾病风险增加的具体原因以及感染后预后较差的可能机制，并提出在应对 COVID-19 的过程中应加强对肥胖人群的保护，并适度延长肥胖感染者的治疗时间。

Abstract：

COVID-19 is a respiratory infectious disease caused by SARS-CoV-2.It has the characteristics of strong infectivity and long incubation period.At present，COVID-19 has spread to several countries around the world，and the number of infected person is still rising.Isolation of positive patients and reduction of gathering people are the main approaches to prevent COVID-19，but effective treatments for COVID-19 are still on the exploration.The relationship between obesity and viral infectious diseases has been confirmed in previous studies，including obese people have a higher risk of viral infectious diseases，obese patients with viral infectious diseases have a worse prognosis.This article reviews the specific reasons for the increased risk of viral infectious diseases in obese people and the possible mechanisms of poor prognosis after infection，and proposes that in the process of responding to COVID-19，the protection of obese people should be strengthened and the treatment time of obese infected people should be extended appropriately.

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