作者：高中山1 ，马玉兰 2

单位：

1.810000 青海省西宁市，青海大学2.810000 青海省西宁市，青海大学附属医院心血管内科

Units：

1.Qinghai University，Xining 810000，China2.Department of Cardiology，Qinghai University Affiliated Hospital，Xining 810000，China

关键词：

冠心病；乳杆菌；动脉粥样硬化

Keywords：

Coronary heart disease；Lactobacillus；Atherosclerosis

CLC：

DOI：

10.12114/j.issn.1008-5971.2021.00.023

Funds：

国家自然科学基金地区科学基金项目（81760084）；青海省科技计划项目（2018-ZJ-934Q）

摘要：

冠心病是目前造成人类死亡的主要疾病之一，据全球死亡率和疾病负担预测 2030 年全球将会有 2 330万人死于冠心病，因此寻找能有效防治冠心病的药物及治疗方案仍非常重要。研究表明，乳杆菌在降低血脂指标、减少三甲胺 N- 氧化物（TMAO）、控制血压、治疗肥胖及控制血糖等方面具有明显效果，其能有效治疗动脉粥样硬化，改善冠心病引起的严重并发症。本文以冠心病的危险因素、发病机制、并发症为切入点，综述了乳杆菌在冠心病预防及治疗中的研究进展，以期为乳杆菌治疗冠心病提供一定理论依据。

Abstract：

Coronary heart disease is currently one of the main diseases that causing human deaths. According to the global mortality and disease burden prediction data，it is predicted that 23.3 million people will die of coronary heart disease in 2030.Therefore，it is still very important to find drugs and other treatment strategies that can effectively prevent and treat coronary heart disease.Studies have shown that Lactobacillus had significant effects in reducing blood lipids，reducing trimethylamine N-oxide（TMAO），controlling blood pressure，treating obesity，and controlling blood sugar.It can effectivelytreat atherosclerosis and improve the severity complications of coronary heart disease.Based on the risk factors，pathogenesis and complications of coronary heart disease，this article reviews the potential mechanism of Lactobacillus in the prevention and treatment of coronary heart disease，providing evidences in the treatment of coronary heart disease by Lactobacillus.

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