作者：张泳巧，范中杰

单位：

100730 北京市，中国医学科学院北京协和医学院 北京协和医院心内科；通信作者：范中杰，E-mail：Fan@pumch.cn

关键词：

细颗粒物；心血管疾病；队列研究；综述

Keywords：

Fine particulate matter；Cardiovascular diseases；Cohort study；Review

CLC：

R 541

DOI：

DOI：10.3969/j.issn.1008-5971.2020.04.002

Funds：

摘要：

细颗粒物（PM2.5）的暴露与心血管疾病具有较强的相关性，是心血管疾病发生和加重过程中可控的危险因素。PM2.5 来源广泛，组成成分复杂，可通过多种生物学机制引起心血管疾病的发生、发展。本文主要综述国内外基于人群的队列研究，评价 PM2.5 对心血管疾病的慢性效应，并总结了 PM2.5 健康危害的干预研究，并提出了我国探索 PM2.5 对心血管疾病慢性效应研究的局限性，为心血管疾病防治提供一些参考和依据。

Abstract：

There is a confirmed causal relationship between PM2.5 exposure and cardiovascular diseases（CVD），PM2.5 is a controllable risk factor for the occurrence and development of CVD.PM2.5，which has a wide range of sources andcomplex components，can cause the occurrence and aggravation of CVD through a variety of biological mechanisms.This paperreviewed population-based cohort studies to evaluate the chronic effects of PM2.5 on CVD and to summarize intervention studieson PM2.5 exposure.We also identified the limitations of previous studies regarding the chronic effects of PM2.5 on CVD in China.Eventually，evidence and lessons for CVD prevention and treatment were generated.

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