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Vol 32, issue 5

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2020 年3 期 第28 卷

COVID-19 专题研究 HTML下载 PDF下载

氯喹和羟氯喹在新型冠状病毒肺炎治疗中的临床研究进展及其心脏毒副作用

Clinical research progress of chloroquine and hydroxychloroquine in the treatment ofCOVID-19 and their cardiotoxicity

作者:刘剑锋1,2 ,张帆 3 ,马守原 1 ,刘念 2

单位:
1.100853 北京市,国家老年疾病临床医学研究中心(中国人民解放军总医院第二医学中心心内科); 2.100029 北京市,首都医科大学附属北京安贞医院心内科; 3.430022 湖北省武汉市,武汉市第一医院心内科;通信作者:刘剑锋,E-mail:shenlangliu@163.com;刘念,E-mail:liunian1973@hotmail.com
关键词:
新型冠状病毒肺炎;新型冠状病毒;氯喹;羟氯喹;心脏毒副作用
Keywords:
COVID-19;SARS-CoV-2;Chloroquine;Hydroxychloroquine;Cardiotoxicity
CLC:
R 563.1
DOI:
DOI:10.3969/j.issn.1008-5971.2020.03.001
Funds:
北京市博士后基金资助项目(2017-zz-126)

摘要:

新型冠状病毒肺炎已在世界范围内大流行,并有可能与人类长期共存,但目前尚无有效抗新型冠状病毒的药物。氯喹和羟氯喹老药新用对新型冠状病毒具有一定疗效,但氯喹和羟氯喹均存在一定心脏毒副作用。本文主要综述了氯喹和羟氯喹在新型冠状病毒肺炎治疗中的临床研究进展、药物特点、心脏毒副作用及其相关机制,以期为提高临床对氯喹和羟氯喹的认识及长期、大范围使用提供参考。

Abstract:

COVID-19 has become a worldwide epidemic at present,which may last for a long time with humanbeings,however there is no effective drugs for COVID-19 so far. Existing drugs,chloroquine and hydroxychloroquine arerepurposed for new indication for COVID-19 and have some positive effects,but there is cardiotoxicity in clinical applicationof chloroquine and hydroxychloroquine. This paper mainly reviewed the clinical research progress in treating COVID-19,characteristics,cardiotoxicity and related mechanisms of chloroquine and hydroxychloroquine,in order to provide a referencefor the understanding,long-term and large-scale use of chloroquine and hydroxychloroquine on clinic.

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