作者：旷湘楠1，2 ，王亚芬 1，2 ，尹玉洁 1，2，3，4 ，王康 1，2 ，李雅文 1，2 ，吴晨 1，3 ，贾振华 1，2，3，4

单位：

1.050090 河北省石家庄市，河北中医学院研究生学院；2.050091 河北省石家庄市，河北以岭医院；3.050035 河北省石家庄市，河北以岭医药研究院 / 国家中医药管理局重点研究室（心脑血管络病）；4.050035 河北省石家庄市，络病研究与创新中药国家重点实验室；通信作者：贾振华，E-mail：jzhjiazhenhua@163.com

Units：

1.Graduate School of Hebei University of Chinese Medicine，Shijiazhuang 050090，China；2.Hebei Yiling Hospital，Shijiazhuang 050091，China；3.Key Laboratory of Hebei Yiling Pharmaceutical Research Institute，Key Laboratory of State Administration of TraditionalChinese Medicine（Cardio-Cerebral Vessel Collateral Disease），Shijiazhuang 050035，China；4.National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine，Shijiazhuang，Shijiazhuang050035，China；Corresponding author：JIA Zhenhua，E-mail：jzhjiazhenhua@163.com

关键词：

慢性阻塞性肺疾病；心血管疾病；共病现象；流行病学；危险因素；治疗；综述

Keywords：

Chronic obstructive pulmonary disease；Cardiovascular diseases；Comorbidity；Epidemiology；Riskfactors；Therapy；Review

CLC：

R 563.9　R 54

DOI：

DOI：10.3969/j.issn.1008-5971.2020.01.001

Funds：

摘要：

慢性阻塞性肺疾病合并心血管疾病被视为“心肺连续体”，但其不能简单地归因于吸烟等共同危险因素，而是存在复杂的心肺交互作用。心血管疾病是慢性阻塞性肺疾病患者重要的共病之一，与慢性阻塞性肺疾病患者住院风险增加、住院时间延长、全因及心血管病相关死亡有关。慢性阻塞性肺疾病合并心血管疾病患者心血管疾病相关经济负担相当大且部分患者对心血管疾病的认识不足，而其治疗共病的累积成本甚至可能超过治疗慢性阻塞性肺疾病本身。本文主要从流行病学、病理生理学及治疗策略等方面系统梳理了慢性阻塞性肺疾病与心血管疾病的关系，以期为临床科学、有效地诊治此类患者提供参考。

Abstract：

Chronic obstructive pulmonary disease（COPD）merged with cardiovascular disease（CVD）is regardedas "cardiopulmonary continuum"，which is attributed to complex cardiopulmonary interaction rather than simply common riskfactors（such as smoking）. CVD，as an important comorbidity of COPD，is associated with increased risk of hospitalization，prolonged hospital stays，all-cause and cardiovascular disease related mortality. Economic burden associated with CVD isconsiderable in COPD patients merged with CVD，and even the cumulative cost in treating comorbidity may exceed that intreating COPD itself，but there is still insufficient awareness of CVD in some patients. This paper systematically reviewed therelationship between COPD and CVD，mainly involving the epidemiology，pathophysiology，therapeutic strategy and so on，inorder to provide a reference for the scientific and effective diagnosis and treatment on clinic.

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