作者：卢紫君 ，黄照河

单位：

1.533000广西壮族自治区百色市，右江民族医学院 2.533000广西壮族自治区百色市人民医院心血管内科

单位（英文）：

1.Youjiang Medical University For Nationalities, Baise 533000, China 2.Department of Cardiovascular Medicine, Baise People's Hospital, Baise 533000, China

关键词：

心肌再灌注损伤；缺氧诱导因子1，α亚基；综述

关键词（英文）：

Myocardial reperfusion injury; Hypoxia-inducible factor 1, alpha subunit; Review

中图分类号：

R 542.2

DOI：

10.12114/j.issn.1008-5971.2023.00.282

基金项目：

国家自然科学基金资助项目（82260883）；广西研究 生教育创新计划项目（YCSW2023505）

摘要：

心肌梗死是影响人类健康的重大疾病之一，临床上以再灌注治疗为其主要治疗手段，而心肌缺血再灌 注损伤（MIRI）是再灌注治疗后常见的一种并发症。缺氧诱导因子（HIF）-1α作为低氧应答的重要分子，能够增强 机体对低氧的适应能力，并参与许多疾病的发生发展。近年来，许多研究表明，HIF-1α可恢复线粒体功能、抵抗氧 化应激以及激活心脏保护性信号通路，从而减轻MIRI，因此其可能成为治疗MIRI的重要靶点。本文主要介绍了HIF- 1α的发现过程、结构与生物学效应及其在MIRI中的作用机制，并总结了基于HIF-1α治疗MIRI的研究现状，以期为 MIRI的诊治提供新思路和理论依据。

英文摘要：

Myocardial infarction is one of the major diseases affecting human health. Reperfusion is the main treatment in clinic, and myocardial ischemia-reperfusion injury (MIRI) is a common complication after reperfusion. Hypoxia inducible factor (HIF) -1α, as an important molecule in hypoxia response, can enhance the body's ability to adapt to hypoxia and participate in the occurrence and development of many diseases. In recent years, many studies have shown that HIF-1α can restore mitochondrial function, resist oxidative stress, and activate cardio-protective signaling pathways, thereby alleviating MIRI, so it may be an important target for MIRI treatment. This article mainly introduces the discovery process, structure and biological effects of HIF-1α and its mechanism of action in MIRI, and summarizes the current research status of treatment of MIRI based on HIF-1 α, in order to provide new ideas and theoretical basis for the diagnosis and treatment of MIRI.

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