作者：程顺昇，徐超凡，康蕊，常宏

单位：

063210河北省唐山市，华北理工大学中医学院

单位（英文）：

Traditional Chinese Medical College, North China University of Science and Technology, Tangshan 063210, China

关键词：

心力衰竭；血管新生；中药；综述

关键词（英文）：

Heart failure; Angiogenesis; Traditional Chinese drugs; Review

中图分类号：

R 541.62

DOI：

10.12114/j.issn.1008-5971.2023.00.302

基金项目：

国家自然科学基金资助项目（81803936）；河北省自 然科学基金资助项目（H2022209031）；河北省中医药管理局科研计 划项目（2024354）；大学生创新创业项目（X2022060）

摘要：

心力衰竭不仅是多种心血管疾病的终末期，也是导致心血管疾病死亡的罪魁祸首。心力衰竭的患病率 居高不下，而促进血管新生在心力衰竭的治疗中起关键作用。目前，西医促进血管新生的方法大多处于实验阶段，没 有确切的临床效果。中药在促进血管新生方面取得了众多研究成果，且中药可以从多方面促进血管新生，从而改善心 力衰竭症状。本文主要综述了中药通过促进血管新生抗心力衰竭的信号通路和靶点，以期为临床从血管新生角度防治 心力衰竭提供参考。

英文摘要：

Heart failure is not only the end stage of many cardiovascular diseases, but also the leading cause of death from cardiovascular diseases. The morbidity rate of heart failure is high, and promoting angiogenesis plays a crucial role in the treatment of heart failure. At present, most methods of Western medicine for promoting angiogenesis are in the experimental stage and have no definite clinical effect. Traditional Chinese drugs have made many research achievements in promoting angiogenesis, which can promoting angiogenesis in many ways to anti-heart failure. This article mainly reviews the signaling pathways and targets of traditional Chinese drugs in anti-heart failure through promoting angiogenesis, and provides reference for the clinical prevention and treatment of heart failure from the perspective of angiogenesis.

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