作者：王聪颖，冯露，孙鑫，陈淑霞，王立立3，谷剑3

单位：

1.075000河北省张家口市，河北北方学院研究生院　2.050051河北省石家庄市，河北医科大学研究生院3.050051河北省石家庄市，河北省人民医院心血管内科

单位（英文）：

1.Graduate School of Hebei North University, Zhangjiakou 075000, China2.Graduate School of Hebei Medical University, Shijiazhuang 050051, China3.Department of Cardiology, Hebei General Hospital, Shijiazhuang 050051, China

关键词：

心力衰竭；可溶性鸟苷酸环化酶；利奥西呱；维利西呱；综述

关键词（英文）：

Heart failure; Soluble guanylyl cyclase; Riociguat; Vericiguat; Review

中图分类号：

R 541.6

DOI：

10.12114/j.issn.1008-5971.2023.00.226

基金项目：

摘要：

心力衰竭（HF）的主要病理生理学特征是内皮功能障碍、炎症和氧化应激，尽管经标准治疗后患者HF症状和体征有了极大改善，但射血分数降低的心力衰竭（HFrEF）和射血分数保留的心力衰竭（HFpEF）患者的全因死亡率和住院率依然很高。在一氧化氮（NO）-可溶性鸟苷酸环化酶（sGC）-环鸟苷酸（cGMP）信号通路中，NO可以通过激活sGC而启动该信号通路，产生第二信使cGMP，从而调节血管扩张和血管平滑肌细胞增殖。而sGC刺激剂具有协同NO和直接刺激sGC的双重作用，故其可能作为新型抗HF药物。本研究综述了sGC刺激剂使HF患者获益的证据及相关机制，以期为寻找HF患者新的治疗方法提供参考。

英文摘要：

The main pathophysiological characteristics of heart failure (HF) are endothelial dysfunction, inflammationand oxidative stress. Although the symptoms and signs of HF have been greatly improved after standard treatment, the all-causemortality and hospitalization rates in patients with heart failure with reduced ejection fraction (HFrEF) and heart failure withpreserved ejection fraction (HFpEF) remain high. In the nitric oxide (NO) -soluble guanylate cyclase (sGC) -cyclic guanylate(cGMP) signaling pathway, NO can activate sGC and start the signaling pathway to produce the cGMP, thereby regulatingvasodilation and vascular smooth muscle cell proliferation. The sGC stimulator has the dual effects of synergistic NO and directstimulation of sGC, so it may be used as a new anti-HF drug. This study reviewed the benefit evidence and related mechanisms ofsGC stimulants in HF patients, in order to provide a reference for finding new treatment methods for HF patients.

参考文献：