作者：由佳鑫，刘羽，唐柏林，王洪新

单位：

锦州医科大学基础医学院

单位（英文）：

Basic Medicine College of Jinzhou Medical University, Jinzhou 121001, China

关键词：

肺动脉高压; 内皮; 平滑肌; 病理性改变; 综述;

关键词（英文）：

Pulmonary arterial hypertension; Endothelium; Smooth muscles; Pathological changes; Review

中图分类号：

DOI：

10.12114/j.issn.1008-5971.2023.00.193

基金项目：

国家自然科学基金资助项目（81973553）

摘要：

肺动脉高压是一种危及生命的严重心肺疾病，其特征表现为内膜和中膜增厚，当前其主要治疗方式为使用血管扩张药物来抑制肺血管收缩，但长期用药会使患者对药物的敏感性降低，导致后期疾病的复发。该病的发生与内皮和平滑肌关系密切。本文总结了内皮与平滑肌的病理性改变（内皮-间质转化、内皮细胞分泌的血管舒缩因子失衡、内皮细胞过度凋亡以及平滑肌细胞过度增殖、平滑肌细胞线粒体功能障碍）在肺动脉高压中的作用，以期为肺动脉高压的发病机制研究提供依据，进而为肺动脉高压的治疗提供参考。

英文摘要：

Pulmonary arterial hypertension is a life-threatening and serious cardiopulmonary disease characterized by thickening of the endothelium and mesothelium, its main treatment is the use of vasodilator drugs to inhibit pulmonary vasoconstriction, but the sensitivity of patients to the drugs decreases after long-term use, leading to recurrence of the disease at a later stage. The development of this disease is closely related to endothelium and smooth muscle. This paper summarizes the role of pathological alterations of endothelium and smooth muscle (endothelial-mesenchymal transition, imbalance of vasodilator molecules secreted by endothelial cells, excessive apoptosis of endothelial cells and excessive proliferation of smooth muscle cells, mitochondrial dysfunction of smooth muscle cells) in pulmonary hypertension , in order to provide a basis for the study of the pathogenesis of pulmonary hypertension, and then for the treatment of pulmonary hypertension.

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