作者：孙海超，姚雨菲，王月娟，刘金腾，张家鸣，魏金荣

单位：

1.225009江苏省扬州市，扬州大学护理学院·公共卫生学院　 2.225009江苏省扬州市中医院护理部 通信作者：魏金荣，E-mail：yzzyywjr@126.com

单位（英文）：

1.School of Nursing, School of Public Health, Yangzhou University, Yangzhou 225009, China 2.Nursing Department, Yangzhou Traditional Chinese Medicine Hospital, Yangzhou 225009, China Corresponding author: WEI Jinrong, E-mail: yzzyywjr@126.com

关键词：

冠心病; 猝死,心脏; 心源性猝死; 危险因素; Meta分析;

关键词（英文）：

Coronary disease; Death, sudden, cardiac; Sudden cardiac death; Risk factors; Meta-analysis

中图分类号：

DOI：

10.12114/j.issn.1008-5971.2022.00.273

基金项目：

江苏省中医药科技发展计划项目（MS2021076）

摘要：

目的 系统评价冠心病患者发生心源性猝死(SCD)的危险因素。方法 计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库、PubMed、Embase、Cochrane Library、Web of Science公开发表的冠心病患者发生SCD危险因素的病例对照研究。检索时限从建库至2022年6月。提取纳入文献的资料，采用纽卡斯尔-渥太华量表(NOS)进行文献质量评价，采用RevMan 5.4.1软件进行Meta分析。结果 本研究纳入28篇文献，共10 382例患者。Meta分析结果显示，高龄、男性、吸烟、饮酒、体质指数升高、情绪不稳定、便秘、糖尿病、高血压、室性心律失常、心肌梗死病史、脑梗死病史、急性肾损伤、血脂异常、房室传导阻滞、肺部感染、三支病变、左主干病变、左心室射血分数(LVEF)下降、TIMI分级≤2级、心率变异性异常、肌酸激酶同工酶(CK-MB)升高、肌钙蛋白升高是冠心病患者发生SCD的危险因素(P<0.05)。结论 冠心病患者发生SCD的危险因素较多，包括高龄、男性、吸烟、饮酒、体质指数、情绪不稳定、便秘、糖尿病、高血压、室性心律失常、心肌梗死病史、脑梗死病史、急性肾损伤、血脂异常、房室传导阻滞、肺部感染、三支病变、左主干病变、LVEF下降、TIMI分级≤2级、心率变异性异常、CK-MB升高、肌钙蛋白升高。

英文摘要：

【Abstract】　Objective To systematically evaluate the risk factors for sudden cardiac death (SCD) in patients with coronary artery disease. Methods Databases including CNKI, Wanfang Data, VIP, CBM, PubMed, Embase, Cochrane Library and Web of Science from inception to June 2022 were retrieved to search for case-control studies on the risk factors for SCD in patients with coronary heart disease. The data of the included literature were extracted, the Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included literature, and RevMan 5.4.1 was used for meta-analysis. Results A total of 28 articles were included, and involving 10 382 patients. The results of meta-analysis showed that, advanced age, male, smoking, alcohol, BMI elevation, emotional instability, constipation, diabetes mellitus, hypertension, ventricular arrhythmia, history of myocardial infarction, history of cerebral infarction, acute renal injury, dyslipidemia, atrioventricular block, pulmonary infection, three-branch lesion, left main stem lesion, left ventricular ejection fraction (LVEF) decline, TIMI class ≤ 2, abnormal heart rhythm, creatine kinase isoenzyme (CK-MB) elevation, and troponin elevation were risk factors for SCD in patients with coronary heart disease (P < 0.05) . Conclusion There are many risk factors for SCD in patients with coronary heart disease, including advanced age, male, smoking, alcohol, BMI elevation, emotional instability, constipation, diabetes mellitus, hypertension, ventricular arrhythmia, history of myocardial infarction, history of cerebral infarction, acute renal injury, dyslipidemia, atrioventricular block, pulmonary infection, three-branch lesion, left main stem lesion, LVEF decline, TIMI class ≤ 2, abnormal heart rhythm, CK-MB elevation, and troponin elevation.

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