2022 年11 期 第30 卷
肺动脉高压专题研究![查看全文 查看全文](/Areas/201911120101/Content/img/icon_html.png)
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肺动脉高压致病基因和靶向治疗研究进展
Research Progress on Pathogenic Genes and Targeted Therapy of Pulmonary Hypertension
作者:王蔚,钟子晴,荀秋芬,祝国风,杨青
- 单位:
- 330006江西省南昌市,南昌大学第二附属医院呼吸与危重症医 学科 通信作者:杨青,E-mail:lisaqing2004@126.com
- 单位(英文):
- Department of Respiratory and Critical Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China Corresponding author: YANG Qing, E-mail: lisaqing2004@126.com
- 关键词:
- 肺动脉高压; 基因组学; 致病基因; 靶向治疗; 综述;
- 关键词(英文):
- Pulmonary hypertension; Genomics; Pathogenic genes; Targeted therapy; Review
- 中图分类号:
- DOI:
- 10.12114/j.issn.1008-5971.2022.00.305
- 基金项目:
- 江西省教育厅科学技术研究项目(GJJ200188)
摘要:
肺动脉高压(PH)是一组以毛细血管前PH为特点的疾病,其治疗棘手,致残率和病死率较高。近年来随着基因检测技术不断发展,与PH相关的基因被越来越多地发现。本文主要综述了PH的致病基因和靶向治疗研究进展,以期为PH的分子机制探索和个体化治疗提供思路。
英文摘要:
【Abstract】 Pulmonary hypertension (PH) is a disease characterized by precapillary PH, which is difficult to treat and has high morbidity and mortality. In recent years, with the development of gene detection technology, more and more genes associated with PH have been found. This article reviews the research progress on pathogenic genes and targeted therapy of PH, in order to provide ideas for molecular mechanism exploration and individualized treatment of PH.
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