作者：姜瑞嘉，程功

单位：

1.710068陕西省西安市，西安医学院 2.710068陕西省西安市，陕西省人民医院心血管内科 通信作者：程功，E-mail：xachenggong@163.com

单位（英文）：

1.Xi'an Medical College, Xi'an 710068, China 2.Department of Cardiovascular, Shaanxi Provincial People's Hospital, Xi'an 710068, China Corresponding author: CHENG Gong, E-mail: xachenggong@163.com

关键词：

心血管疾病; 动脉粥样硬化; 动脉粥样硬化性心血管疾病; 胆固醇,LDL; 低密度脂蛋白胆固醇;

关键词（英文）：

Cardiovascular diseases; Atherosclerosis; Atherosclerotic cardiovascular disease; Cholesterol, LDL; Low density lipoprotein cholesterol

中图分类号：

DOI：

10.12114/j.issn.1008-5971.2022.00.288

基金项目：

陕西省中医药管理局委托办事经费任务（2021-ZZ ZY003）；心馨-默克心血管科研基金资助项目（Y20170719）

摘要：

动脉粥样硬化性心血管疾病(ASCVD)是导致人群死亡和致残的主要原因，临床研究已证实，在所有可改变的心血管危险因素中，低密度脂蛋白胆固醇(LDL-C)升高与ASCVD的发生最为相关。本文回顾了各种降脂治疗的临床研究，总结了不同研究中ASCVD患者LDL-C的安全低值，分析表明低水平LDL-C既可保证临床治疗的有效性，又不增加临床风险，目前认为ASCVD患者LDL-C的安全低值为<1.40 mmol/L，这为ASCVD患者的临床治疗提供了参考。

英文摘要：

【Abstract】 Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and disability in the population, and it has been clinically demonstrated that among all modifiable cardiovascular risk factors, elevated low-density lipoprotein cholesterol (LDL-C) is most associated with the development of ASCVD. This paper reviews the clinical studies of various lipid-lowering treatments, and summarizes the safe and low levels of LDL-C in ASCVD patients in different studies. Analysis shows that low levels of LDL-C can not only ensure the effectiveness of clinical treatment, but also do not increase clinical risks. Currently, it is believed that the safe low value of LDL-C in ASCVD patients is less than 1.40 mmol/L, which provides a reference for the clinical treatment of ASCVD patients.

参考文献：